Testosterone influences renal electrolyte excretion in SHR/y and WKY males

BMC Physiology

Table 1 Serum Testosterone and Systolic Blood Pressure at 15 Weeks

Strain	Treatment	Serum Testosterone (ng/ml)	Systolic Blood Pressure (SBP, mmHg)	Relative Kidney Weight (mg/100 g BW)
SHR/y	control	5.6 +/-1.4	^+++,&&&155.8+/-3.1	764+/-36.0
SHR/y	cast	0.05+/-0.02	136.8+/-1.6	^###616+/-23.0
SHR/y	cast +Ti	⁺⁺⁺14.84+/-0.51	142.2+/-2.4	^$$916+/-19.0
WKY	control	3.28+/-0.16	137.6+/-2.3	658+/-17.0
WKY	cast	0.19+/-0.07	^%126.0+/-4.6	636+/-24.0
WKY	cast +Ti	⁺⁺⁺12.44+/-2.00	144.4+/-5.7	783+/-77.0

Serum testosterone (T) levels, systolic blood pressure and relative kidney weight at 15 weeks of age for SHR/y and WKY gonadally intact control (control), castrate (cast) and castrate with T implant (cast+Ti) males, expressed as means +/- SEM. The two-way ANOVA for serum T was significant for T treatment) F = 226.0, p < 0.001). Both T implant groups had elevated T compared to controls (⁺⁺⁺ = p < .001). The two-way ANOVA for SBP was significant for T treatment (F = 8.1, p = 0.005), strain (F = 6.2, p = 0.001), and T treatment x strain (F = 4.9, p = 0.003). The two-way ANOVA for T treatment on relative combined kidney weight was significant (F = 99.1, p < 0.001). The SHR/y control group SBP was greater than the SHR/y cast+Ti (⁺⁺⁺ = p < 0.01) and SHR/y cast group SBP (^&&&= p < 0.001). The WKY cast group SBP was less than the WKY cast+Ti and control groups (^% = p < 0.05). Relative combined kidney weight for SHR/y cast was significantly less than SHR/y control and SHR/y cast +Ti groups (^### = p < 0.001). relative combined kidney weight for the SHR/y cast +Ti group was significantly greater than the SHR/y cast and control groups (^$$ = p < 0.01).

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