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Figure 1 | BMC Physiology

Figure 1

From: Decrease of PECAM-1-gene-expression induced by proinflammatory cytokines IFN-γ and IFN-α is reversed by TGF-β in sinusoidal endothelial cells and hepatic mononuclear phagocytes

Figure 1

Indirect immunodetection of PECAM-1, ICAM-1, and ED1 in sections of normal rat or acutely damaged livers (48 h after a single CCl 4 -administration). Sections of normal rat liver tissue (a, c, e) or acutely damaged rat liver tissue (b, d, f) were stained with a monoclonal antibody directed against rat PECAM-1 (a, b), ICAM-1 (c, d), ED1 (e, f), followed by the APAAP immunodetection (Original magnification × 250). Figures 1g and 1h are the negative control, which was performed with murine serum. Note that in the necrotic areas around the central vein most of the ED1-positive cells representing inflammatory MNPs are PECAM-1 negative, but ICAM-1 positive.

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BMC Physiology

ISSN: 1472-6793

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