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Figure 2 | BMC Physiology

Figure 2

From: Decrease of PECAM-1-gene-expression induced by proinflammatory cytokines IFN-γ and IFN-α is reversed by TGF-β in sinusoidal endothelial cells and hepatic mononuclear phagocytes

Figure 2

(A) Expression of TNF-α, IFN-γ, and TNF-β during acute liver damage (CCl 4 -model). Livers taken at different time points after a single administration of CCl4 were homogenized and used with a human-TNF-α and human-TNF-β EIA-kit or rat-IFN-γ ELISA-kit. Cytokine concentration is indicated as pg per mg of liver wet weight. Error bars indicate standard deviation of the mean value of four experiments from four different animals. (B) Western Blot analysis of p-SMAD2/3 and p-STAT-1 in SECs during acute liver damage (CCl4-model). SECs from untreated control rats (c) and different time points after CCl4 administration were isolated. β-actin was used as loading control (not shown). Consistent data could be shown in SECs isolated from two different rats for each time point.

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BMC Physiology

ISSN: 1472-6793

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