From: Regulation of excitation-contraction coupling in mouse cardiac myocytes: integrative analysis with mathematical modelling
Magnitude
Simulated value
Experimental value
Quiescent [Na+]i (mM)
13.6
16.4 ± 0.7 [66]; 15.6 ± 0.7 [66]; 12.5 ± 1.8 [67]
Quiescent [K+]i (mM)
143.0
~140 [81]
Quiescent EK (mV)
-84.1
~-80 [81]
Quiescent V (mV)
-79.0
~EK [81]
AP amplitude (mV) at 1 Hz
110.6
106 ± 11 [20]; 118 [68]
AP 50% duration (ms) at 1 Hz
3.25
4.5 ± 0.3 [69]; 2.6 ± 0.1 [59]; 1.6 ± 0.2 [20]
dV/dtmax (V/s) at 1 Hz
148.4
161 ± 44 (neonatal cell culture) [70]
193.25 ± 13.94 (rat) [71]; 133.8 ± 9.2 (42 days old) [58]