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Table 1 Comparison of the AP properties of the model and experimental data

From: Regulation of excitation-contraction coupling in mouse cardiac myocytes: integrative analysis with mathematical modelling

Magnitude

Simulated value

Experimental value

Quiescent [Na+]i (mM)

13.6

16.4 ± 0.7 [66]; 15.6 ± 0.7 [66]; 12.5 ± 1.8 [67]

Quiescent [K+]i (mM)

143.0

~140 [81]

Quiescent EK (mV)

-84.1

~-80 [81]

Quiescent V (mV)

-79.0

~EK [81]

AP amplitude (mV) at 1 Hz

110.6

106 ± 11 [20]; 118 [68]

AP 50% duration (ms) at 1 Hz

3.25

4.5 ± 0.3 [69]; 2.6 ± 0.1 [59]; 1.6 ± 0.2 [20]

dV/dtmax (V/s) at 1 Hz

148.4

161 ± 44 (neonatal cell culture) [70]

193.25 ± 13.94 (rat) [71]; 133.8 ± 9.2 (42 days old) [58]