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Table 4 Initial conditions for the differential parameters

From: Regulation of excitation-contraction coupling in mouse cardiac myocytes: integrative analysis with mathematical modelling

Parameter

Description

Value (μM)

Refs.

CaM

Calmodulin

6

[75]

CaMK

Basal activity of Ca2+/Calmodulin-dependent Kinase

10*

[17]

total_CaMK

Total amount of Ca2+/Calmodulin-dependent Kinase (buffered)

10*

[17]

CaNAB_Ca2

Calcineurin with two Ca2+-sites occupied

1

[46]

I1

Unphosphorylated form of Protein Phosphatase Inhibitor-1

1.8

[46]

I1_x

Phosphorylated form of Protein Phosphatase Inhibitor-1

0.001

[46]

PP1_active

Phosphorylated form of Protein Phosphatase 1

1.8

[46]

tot_PP1

Total concentration of Protein Phosphatase 2A

1.8

[17]

PP2A

Phosphorylated form of Protein Phosphatase 2A

0.12

[46]

PKA_active

Phosphorylated form of Protein Kinase A (buffered)

0.014735

[17]

---

Parameters of the action potential model.

---

[53]

---

Parameters of the contraction model.

---

[54]

  1. * A simplified approach to represent the 10 subunits, when CaMK concentration is 1 μM.