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Table 2 Genes with overlapping but opposite alteration in ISO-treated and exercise mouse hearts

From: Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure

Gene ID

Gene Name

Gene Symbol

Function

ISO

Swim

    

FC

p

FC

p

BE133150

ESTs

NA

Unknown

2.0

0.002

-2.1

0.011

BC019553

cDNA

NA

Unknown

2.6

0.002

-2.9

0.002

BI180630

ESTs

NA

Unknown

2.0

0.007

-2.1

0.007

BM234799

cDNA

NA

Actin cytoskeleton organization

1.7

0.009

-2.0

0.006

BB283973

cDNA

NA

Unknown

-3.1

0.010

2.4

0.020

AW537707

Actin, beta, cytoplasmic

Actb

Non-muscle cytoskeletal constituent

-3.0

0.009

1.8

0.009

NM_007398

Adenosine deaminase

Ada

Smooth muscle contraction; immune response

2.2

0.004

-1.9

0.005

AV229424

Collagen, type V, alpha 2

Col5a2

Extracellular matrix structural constituent

2.2

0.022

-2.2

0.005

NM_010188

Fc receptor, IgG, low affinity III

Fcgr3

Antigen processing and presentation via MHC class I

2.1

0.006

-1.6

0.003

BC004724

Fibronectin 1

Fn1

Acute-phase response; cell-matrix adhesion

2.3

0.020

-1.7

0.005

AK012898

Glycine/arginine rich protein 1

Grrp1

Unknown

3.5

0.005

-2.3

0.005

BB269715

Hypoxia inducible factor 1, alpha subunit

Hif1a

Angiogenesis; neural crest cell migration; response to hypoxia

-1.9

0.002

2.0

0.002

BE995678

Heat shock protein 90, beta (Grp94), member 1

Hsp90b1

Stress response

-8.4

0.009

3.4

0.014

NM_030127

HtrA serine peptidase 3

Htra3

Regulation of cell growth

1.8

0.006

-2.2

0.006

BC003209

Integrator complex subunit 3

Ints3

snRNA processing

2.2

0.006

-2.7

0.006

NM_008606

Matrix metallopeptidase 11

Mmp11

Collagen catabolism

2.3

0.013

-1.9

0.006

NM_010929

Notch gene homolog 4

Notch4

Patterning of blood vessels; cell fate determination

2.0

0.005

-2.0

0.006

AK013448

Protein phosphatase 1, regulatory (inhibitor) subunit 14c

Ppp1r14c

Signal transduction

-2.8

0.002

2.2

0.003

BE137091

Regulatory solute carrier protein, family 1, member 1

Rsc1a1

Regulation of protein transport and modification

2.0

0.005

-1.8

0.006

NM_011581

Thrombospondin 2

Thbs2

Inhibits microvascular endothelial cell proliferation; cell adhesion; wound repair

2.2

0.002

-1.7

0.004

  1. FC = fold-change. Dash ("-") before number indicates down-regulation, compared to appropriate controls. NA - not applicable, where a gene without a gene symbol was identified as altered in expression (i.e., cDNA, EST, or gene encoding a hypothetical protein). ISO and Swim = Control mice versus isoproeteronol-treated or exercised mice, respectively. Gene functions were obtained from Ingenuity pathway analysis software, supplemented with information obtained from the NCBI and Stanford SOURCE search databases.