Table 3 Comparison of Multiple Cardiac Hypertrophy Studies

Physiological CH Models

This Study

C57BL/6 mice

Affy 430 2.0

Control

8 wk

3

2,351

-

139/20

Swim

3

GSE77^a [11]

FVB mice

Affy U74Av2

Control

10 min

3

141

2/26

5/6

Swim

3

Swim

2.5 day

3

32

10/2

4/3

Swim

1 wk

3

41

11/3

8/2

Swim

2 wk

3

77

9/7

10/9

Swim

3 wk

3

51

2/1

8/3

Control

4 wk

3

68

14/14

6/5

Swim

3

Control

4 wk/1 wk

3

13

2/1

1/1

Swim/Rest

3

GSE739^b [12]

Wistar rats

Affy U34A

Sedentary

7 wk

6

39

1/2

7/1

Treadmill

6

GSE7640^a [13]

Rats [d]

Affy 230 2.0

Sedentary

10 wk

10

18

1/0

1/0

Mild exercise

10

GSE776^a [14]

Dahl rats

Affy U34A

Sedentary

3 wk

3

293

20/40

7/18

Treadmill

3

Sedentary

6 wk

3

282

12/36

8/14

Treadmill

3

GSE9445^a [15]

N:NIH LCR rats

Affy 230 2.0

Sedentary

8 wk

4

19

0/1

2/0

Treadmill

4

N:NIH HCR rats

Sedentary

4

42

1/1

2/1

Treadmill

4

Diffee et al^c [16]

Sprague-Dawley rats

Affy U34A

Sedentary

11 wk

9

27

1/1

1/4

Treadmill

9

Iemitsu et al^c [17]

Atlas 3.8I

Sedentary

8 wk

8

75

4/5

1/1

Treadmill

8

Pathological CH Models

This Study

C57BL/6 mice

Affy 430 2.0

Control

10 day

3

808

139/20

-

ISO-treated

3

Kim et al^c [31]

FHC

Mice [d]

PMAGE

Wild-type

8 wk

4-5

706

215/272

121/79

αMHC^403/+

25 wk

GSE1621^a [20]

FVB mice

Affy U74av2

Sham

48 hr

4

15

0/3

4/1

TAC

5

Sham

10 day

4

106

9/30

10/5

TAC

5

Sham

3 wk

4

95

8/21

13/3

TAC

5

GSE2459^b [21]

FVB mice

Affy U74av2

Sham

10 wk

9

307

14/24

14/7

TAC

6

GSE1145^a [25]

Humans

Affy 133 2.0

Normal

N/A

11

-

-

-

Idiopathic dilated

15

2,480

124/200

35/99

Ischemic

11

1,214

66/74

38/45

Affy U95A

Normal

4

-

-

-

Aortic stenosis

7

57

5/4

4/2

Congenital

6

354

10/50

1/18

GSE738^b [22]

Wistar rats

Affy U34A

Sham

3 wk

2

50

1/8

2/1

Shunt

2

Sham

8 wk

2

32

0/5

2/2

Shunt

2

Sham

3 wk

2

55

4/8

12/1

Myocadial infarction

4

Sham

9 wk

2

99

4/15

5/4

Myocadial infarction

4

Sham

6 wk

2

64

6/1

6/1

Aortic banding

2

Sham

12 wk

2

21

2/1

3/0

Aortic banding

2

Sham

16 wk

2

101

5/6

3/2

Aortic banding

2

Sham

30 wk

2

107

5/15

10/3

Aortic banding

4

Vehicle

2 wk

2

-

-

-

Ang2

2

28

0/1

3/0

Dipta

2

5

0/1

0/0

GSE5500^a [23]

Mice [e]

Affy 430 2.0

Sham

7 day

4

-

23/74

39/10

TAC

6

470

GSE12337^a [24]

Mice [d]

Affy 430 2.0

Sham

28 day

4

-

0/8

2/0

TAC

4

12

GSE775^b [19]

Mice [d]

Affy U74Av2

Control

1 wk

4

1,585

69/127

93/29

Myocardial infarction

3

Control

8 wk

4

698

48/34

23/14

Myocardial infarction

3

GSE776^a [14]

Dahl rats

Affy U34

Control

3 wk

3

-

2/9

8/7

High salt diet

3

62

Control

6 wk

3

40/24

15/6

High salt diet

3

315

Control

15 wk

3

-

37/11

36/3

High salt diet

3

224