Skip to main content

Table 4 Genes altered in response to exercise, grouped by function

From: Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure

Gene

Physiological

Pathological

 

This study

Swim

Tread

Drug

RQ

MI

AB

Sh

MI

Salt

Idiop

Isch

AS

Cong

 

Mice

Rats

Mice

Rats

Humans

 

FC

Cell adhesion/migration

Acta2

-3.2

-1.9

 

-3.7

1.7

  

1.8

 

1.6

-2.6

    

Aplp2

-1.7

 

-2.1

 

+/-

          

Lmo7

1.8

 

1.7

  

-8.2

     

-1.5

-1.5

  

Ap2s1

-2

 

-1.6

       

1.7

    

Cellular assembly and organization

Itga7

-2.8

 

-1.6

       

-1.5

    

Nfia

1.9

 

1.9

     

-1.6

 

-2.3

    

Sorbs1

11.3

2.1

  

d

-6.7

         

Tmsb10

-2.6

-1.5

   

2.8

2.3

   

-2.1

    

Cell death

Aes

-2.2

 

-1.9

 

+/-

-5.2

   

1.6

1.8

    

Akap1

-1.9

 

-1.7

-2.1

-2.6

-7.3

    

1.9

    

Cd74

-3.8

-2.1

-1.7

-3.1

      

1.7

 

1.5

  

Cd99

-2.1

-1.6

   

-3.2

         

Crp

2.3

 

1.7

       

-2

    

Cyb5r3

-2.3

 

-1.6

 

i

          

Fbn1

-2.8

-1.5

   

2.9

2.2

     

1.5

  

Gsk3b

6.2

 

1.6

       

-1.6

-2.2

-1.7

  

H2-D1

-3.3

-1.6

             

Kcnk3

-2.6

 

-2

 

d

-13.5

    

2.3

 

-1.8

  

Lamb2

-2.3

 

-1.7

  

-3.3

         

Mapt

-2.2

-1.7

   

-15.4

     

2.4

2.8

  

Nfkbia

-2.7

-1.6

        

1.5

-1.9

   

Nme3

-2

-1.5

   

-3

         

Nupr1

-2.5

 

-1.5

 

3.3

3.6

         

Pitpna

-1.8

 

-1.5

        

-1.8

   

Ppargc1a

7

2.5

   

-7.3

         

Ppp2r1a

-1.9

 

-2.9

 

+/-

     

2.3

    

Tfrc

-4.2

 

-1.5

-12.3

10.1

     

1.8

-1.6

-1.7

  

Cell growth and development

Dbp

-2.8

-1.6

2.2

 

+/-

  

-1.9

  

-2.4

    

Gna12

-2.4

-1.5

       

1.5

     

Ltbp4

-3

-1.7

  

i

 

1.6

     

1.7

  

Nedd8

-1.7

-1.6

             

Pctk1

-1.7

 

-1.6

 

9

          

Heart contraction

Dmpk

-3.2

-1.6

   

-5.2

         

MHC-β

11.5

3.4

 

2.7

  

4.5

2.6

 

1.9

2.3

1.6*

2.5*

  

Immune functions

C1qa

-2.1

-1.5

  

3.4

1.7

1.7

        

C1qc

-2.4

-1.5

   

1.7

1.7

        

Col1a1

-4.7

-1.6

  

+/-

3.4

2.4

 

1.7

2

-2.6

1.6

1.8

 

1.5

Col3a1

-3.1

-1.6

-1.8

 

2.2

4.9

3.1

1.6

1.7

2.5

-2.9

1.5

2

  

Fabp4

2.7

 

1.7

       

-1.7

    

H2-Aa

-3

-1.6

 

-3.9

 

1.9

         

H2-K1

-2.9

-1.7

  

6

          

Psmb8

-2.5

-1.6

  

2.3

          

Extracellular matrix organization

Adam19

-2.3

-1.6

    

1.5

        

Col15a1

-3.2

-1.6

 

-2.8

+/-

2.1

2.3

   

-2.7

    

Matr3

2.1

 

1.6

 

1.7

          

Timp3

4.5

1.6

-1.5

        

-1.5

   

Other or unknown

Ccdc53

-1.9

 

-1.5

            

Ccdc56

-2.1

 

-2.1

 

-2.6

     

2.2

    

Ell2

5

1.8

 

2.4

 

-2.2

     

-1.9

-1.8

  

Fstl1

-2

-1.6

   

6.6

2.8

1.8

 

1.9

-1.6

    

Gas5

-2.5

-1.7

         

-1.8

   

Kank3

-2.1

-1.7

             

Lipa

-2.6

 

-1.7

    

-1.6

       

Ptrf

-2.4

-1.6

  

+/-

         

1.5

Slc29a4

1.8

1.7

             

Snrp70

2.2

 

1.6

       

-1.6

    

Ssbp1

-1.7

 

-1.5

            

Tsc22d4

-2.2

-1.5

 

-1.9

d

-2.9

         

Ttc3

2.4

 

1.6

 

+/-

       

1.5

  
  1. FC = fold-change. Dash ("-") before number indicates down-regulation, compared to appropriate controls. A blank indicates that no significant alteration (fold change at least 1.5, p value ≤ 0.05) was observed. The asterisk indicates that a variant of MHC-β (MYH7B) was up-regulated. For PMAGE data, "i" and "d" indicate induction and down-regulation with 0 transcripts detected in either wild-type or αMHC403/+ mice, respectively. Where genes that were represented by more than one polony (analogous to a probe set) conflicted in direction (one or more up-regulated sequence tags and one or down-regulated sequence tags representing the same gene), "+/-" is used in place of a FC value. Gene highlighted in bold font was a consistent finding (down-regulated in exercised rodents and up-regulated in various pathological cardiac hypertrophy conditions). Idiop, Isch, AS, and Cong = idiopathic, ischemic, aortic stenosis, and congenital, respectively. "Drug" refers to isoproterenol, angiotensin II, or 3,5-diiodothyropropionic acid treatment. Sh, MI, and AB = shunt, myocardial infarction, and aortic banding, respectively. RQ = αMHC403/+ mice, representing familial cardiac hypertrophy. Gene functions were obtained from Ingenuity pathway analysis software, supplemented with information obtained from the NCBI and Stanford SOURCE search databases. Some genes perform more than one function, but are only listed under one category.