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Table 5 Genes altered under conditions of pathological cardiac hypertrophy, grouped by function

From: Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure

Gene

Pathological

Phys

 

This Study

RQ

MI

AB

Sh

MI

Drug

Salt

Idiop

Isch

AS

Cong

Exercise

 

Mice

Rats

Humans

Rodents

 

FC

Cell adhesion and migration

Aoc3

2.2

        

1.5

    

Itgbl1

2.4

  

1.8

     

1.6

2.8

   

Ltbp2

3.3

 

13.1

2

     

1.7

2.5

   

Omd

2.6

 

5.1

      

1.9

2.6

  

2.4

Cardiovascular functions and/or disease association

Angptl2

-2.2

  

1.7

     

-1.5

   

-2.3

Atp1a1

-1.9

d

-4.0

   

1.8

 

2.3

-1.7

-1.6

  

-5.3

Ctgf

3.7

2.1

3.1

2.7

      

1.5

2.2

 

-3.5

Dcn

2.8

1.8

    

1.6

 

1.7

 

1.6

  

-1.6

Fbxw7

-1.8

        

-1.5

    

Fn1

2.3

1.9

1.8

3

1.7

 

1.9

 

1.6

-1.6

-1.6

2

 

2

Hif1a

-1.9

  

1.5

     

-1.9

   

-1.5

Hyou1

-1.8

       

-1.9

-1.7

    

Kdr

-1.9

7

      

-1.7

-1.5

   

2.3

Lox

10.1

 

24.6

3.5

    

1.5

 

2

   

Mef2c

-2.2

 

-3.1

      

-1.6

    

MHC-β

2.7

  

4.5

2.6

 

1.9

 

2.3

1.6*

2.5*

   

Prox1

-1.8

 

-20

-1.5

     

-1.8

-1.6

   

Sfrs2

-2.7

           

-1.7

3.4

Thbs2

2.5

 

7

       

1.8

   

Cell-cell signaling

Palld

-3.4

        

-1.9

   

2

Ramp1

-3

         

-1.6

   

Cellular Movement

Trak1

-2

        

-1.6

    

Tuba4a

-6

 

-7.7

     

-2.8

 

-1.7

   

Tubb2a

-2

  

1.6

     

-1.6

    

Cell cycle arrest and/or cell death

Ddit4

7

          

1.9

 

-2.2

Il17rd

1.9

         

1.6

   

Isg20l1

-1.6

        

-1.6

   

-3.6

Prmt1

-2.1

        

-1.8

    

Scn7a

2.1

   

-2.1

     

1.9

   

Development

Ezh1

1.9

         

1.8

   

Hopx

-2.5

 

-18.5

      

-2.5

-3.1

   

Slc40a1

2.1

       

1.5

1.6

2.1

  

-1.7

Ttll7

4.2

        

1.7

    

Cell growth/proliferation

Brd4

-1.8

        

-1.6

    

Ccng2

3

-1.7

        

1.8

   

Cdh13

-8.3

d

-6.7

         

-2

 

Clu

2.1

2.7

 

1.7

1.5

 

1.6

 

1.8

  

1.5

 

-1.5

Cthrc1

3.5

  

2.5

      

2.4

   

Egr1

-3.3

  

1.9

-1.7

1.8

  

1.6

-2.2

1.9

  

-2.8

Fkbp4

-2.6

 

-7.2

 

-1.6

   

-2.1

-1.6

-1.5

   

Hipk2

-2

4

       

-1.5

-1.6

  

-1.6

Hk2

-2

 

-6.9

     

-1.8

-1.7

   

1.5

Hsp90b1

-8.4

-1.6

       

-1.6

    

Kif1b

-3.6

3

-3.6

      

-1.6

    

Mlf1

-2

-2.1

-25.2

         

-1.5

-2

Nox4

4.7

         

1.6

   

Pdgfd

1.9

       

-1.6

 

2.1

   

Plagl1

2.4

 

3.5

       

1.8

  

-4.2

Plcb4

1.8

         

1.6

   

Postn

4.1

3.1

5.8

7.1

4.8

 

3.9

2

  

2.8

  

-2.2

Tfrc

-12.3

10

      

1.8

-1.6

-1.7

  

-1.5

Trp53inp1

4.3

         

1.5

   

Extracellular matrix morphology

Aspn

2.6

1.6

 

3

2

 

1.8

  

2.6

4.5

   

Cilp

3.8

5.4

 

2.8

      

1.9

   

Fbln2

1.7

1.5

3.2

2.1

     

1.6

1.6

  

2.2

Mfap5

3.1

1.5

3.8

2.9

      

1.8

  

-4.2

Other or unknown

Arrdc3

2.1

         

1.8

   

Dhrs7

-1.6

        

-1.5

    

Hs2st1

-2

 

1.8

      

-1.8

    

Kcnt2

2.2

        

-1.9

1.6

   

Klhl24

2.7

 

-3.1

       

1.6

  

-1.6

Obfc2a

-2.1

        

-1.8

   

-1.7

Pcmtd2

2.1

    

-1.8

    

1.6

  

-3

Reep1

-2.8

 

-3.9

      

-2.5

-1.7

   

Rnase4

2

 

2.6

     

1.5

 

1.9

   

Trmt5

2.4

i

        

1.5

   

Tsfm

-1.7

 

-3.6

      

-1.5

    

Zbtb44

2

        

-1.6

1.6

   

Zfp428

-2.2

           

1.5

 
  1. FC = fold-change. Dash ("-") before number indicates down-regulation, compared to appropriate controls. A blank indicates that no significant alteration (fold change at least 1.5, p value ≤ 0.05) was observed. The asterisk indicates that a variant of MHC-β (MYH7B) was up-regulated. For PMAGE data, "i" and "d" indicate induction and down-regulation with 0 transcripts detected in either wild-type or αMHC403/+ mice, respectively. Idiop, Isch, AS, and Cong = idiopathic, ischemic, aortic stenosis, and congenital, respectively. "Drug" refers to angiotensin II treatment. (No gene alterations in common with ISO treatment were found for 3,5-diiodothyropropionic acid treated-rats.) Sh, MI, and AB = shunt, myocardial infarction, and aortic banding, respectively. RQ = αMHC403/+ mice, representing familial cardiac hypertrophy. Phys = physiological. Gene functions were obtained from Ingenuity pathway analysis software, supplemented with information obtained from the NCBI and Stanford SOURCE search databases. Some genes perform more than one function, but are only listed under one category.
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BMC Physiology

ISSN: 1472-6793

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