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Figure 4 | BMC Physiology

Figure 4

From: Intestinal barrier function in response to abundant or depleted mucosal glutathione in Salmonella-infected rats

Figure 4

Inflammation and oxidative damage in the ileummucosa. BSO increased inflammation in the ileum mucosa of S. enteritidis infected rats. S. enteritidis infected (n = 8 per diet) and non-infected (n = 6 per diet) rats were fed the control diet (white bars) or the same diet supplemented with BSO (grey bars) or cystine (black bars). Mucosal levels of the pro-inflammatory cytokine interleukin-1β (IL-1β) and myeloperoxidase (MPO) are shown in panels A and B, respectively. Recovery experiments with purified IL-1β and MPO, added to the mucosal samples, were included in each assay and confirmed the absence of inhibiting factors in the ileal samples. Oxidative damage to ileal proteins was determined by measurement of protein carbonyls (C). All results are expressed as means ± SE. An asterisk indicates a significant difference from the control diet group (either non-infected or infected rats; p < 0.05).

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