Figure 1

Effect of MK2-deficiency on morbidity and mortality in systemic inflammation and sepsis. (A-B) Body temperature and mortality for WT (n=3) and MK2^-/- (n=5) mice after i.v. injection of 10μmg/kg LPS. (C) Body temperature for WT (n=5) and MK2^-/- (n=9) mice after i.v. injection of 50 or 125μg/kg TNF. Dose groups were pooled together because statistical comparison within one genotype revealed no differences. (D) Mortality for WT (n=10) and MK2^-/- (n=13) mice after i.v. injection of 10, 50, 125 or 250μg/kg TNF. Dose groups were pooled together because statistical comparison within one genotype revealed no differences. (E) Mortality for WT (n=9) and MK2^-/- (n=10) mice after CLP surgery. Survival curves of different genotypes were compared via log-rank test. ****, p≤0.0001; **, p≤0.01.