Figure 5

Vascular permeability assessed by extravasation of FITC-Dextran (4 kDa). FITC-Dextran quantification for WT and MK2^-/- mice, 2.5 h after i.v. injection of 450μg/kg TNF for liver (A), kidney (B), lung (C), heart (D), and spleen (E); (n=5 × 2 for liver, kidney and lungs; n=5 for heart and spleen). Comparisons were made between baseline (PBS) and TNF challenged animals (#), and between genotypes (*) via one-way ANOVA with Sidak’s multiple comparisons test. Error bars indicate SD. ***, p≤0.001; **, p≤0.01; *, p≤0.05.