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Table 2 Hemodynamic measurements during experimentation. Data represent mean ± SEM of measures taken every 30 min under sham operated animals (CON), cerebral hypoxia (CH), and global hypoxia (GH). Baseline values were measured prior to induction of experimental conditions. The last column in the table represents the mean ± SEM of all time points considering baseline measurements as covariates

From: Hypoxia mediated pulmonary edema: potential influence of oxidative stress, sympathetic activation and cerebral blood flow

Measures

Groups

Baseline

30 min

60 min

90 min

120 min

Mean ± SEM at all time points

HR

CON

116 ± 5

118 ± 14

134 ± 19

122 ± 22

124 ± 9

119 ± 15

(bpm)

CH

111 ± 4

116 ± 12

107 ± 5

117 ± 10

124 ± 9

114 ± 10

 

GH

90 ± 6

111 ± 12

98 ± 11

101 ± 13

103 ± 9

111 ± 15

MAP

CON

65 ± 6

78 ± 12

85 ± 1

82 ± 2

83 ± 8

86 ± 4

(mmHg)

CH

84 ± 11

82 ± 6

67 ± 6

74 ± 4

73 ± 6

73 ± 2*

 

GH

81 ± 3

80 ± 2

77 ± 3

79 ± 2

77 ± 2

78 ± 3

PAP

CON

15 ± 1

14 ± 3

15 ± 1

14 ± 2

15 ± 1

15 ± 2

(mmHg)

CH

22 ± 4

22 ± 2

20 ± 2

23 ± 1

25 ± 1

23 ± 1*

 

GH

22 ± 2

28 ± 2

24 ± 2

29 ± 3

29 ± 3

27 ± 2*

Pwedge

CON

11.7 ± 0.6

12.0 ± 0.6

11.7 ± 0.7

12.3 ± 1.2

12.3 ± 0.9

12.5 ± 0.9

(mmHg)

CH

14.2 ± 0.9

13.2 ± 0.8

13.0 ± 0.5

12.3 ± 0.9

12.5 ± 0.9

12.7 ± 0.5

 

GH

15.8 ± 1.3

15.0 ± 1.2

13.8 ± 1.3

14.8 ± 0.3

15.0 ± 0.4

14.4 ± 0.7

CO

CON

2.6 ± 0.3

3.1 ± 0.8

3.3 ± 0.7

3.2 ± 0.9

3.7 ± 0.6

3.8 ± 0.5

(L/min)

CH

4.3 ± 1.2

4.3 ± 1.0

4.1 ± 0.7

4.1 ± 0.4

3.8 ± 0.3

3.9 ± 0.3

 

GH

3.9 ± 0.4

5.4 ± 1.0

5.1 ± 0.4

5.2 ± 0.7

5.1 ± 0.7

5.2 ± 0.4*#

ICP

CON

12 ± 3

10 ± 2

11 ± 2

11 ± 3

11 ± 3

14 ± 2

(mmHg)

CH

21 ± 3

22 ± 3

21 ± 2

21 ± 3

22 ± 3

17 ± 1

 

GH

11 ± 2

7 ± 2

10 ± 4

9 ± 3

11 ± 5

13 ± 2

SV

CON

23.3 ± 3.4

29.3 ± 11.5

26.8 ± 8.3

28.6 ± 9.5

34.1 ± 9.9

35.4 ± 4.3

(mL)

CH

40.8 ± 12.4

39.9 ± 8.7

39.7 ± 7.3

35.9 ± 3.5

31.7 ± 3.1

35.7 ± 2.9

 

GH

44.8 ± 6.1

48.2 ± 3.9

53.2 ± 4.3

52.7 ± 7.0

50.2 ± 5.7

48.4 ± 3.6*#

PVR

CON

1.7 ± 0.9

3.1 ± 0.8

1.5 ± 0.4

2.6 ± 0.7

2.5 ± 0.5

2.4 ± 0.7

(dyn*s/cm^5)

CH

2.1 ± 0.5

3.6 ± 1.9

2.1 ± 0.6

2.6 ± 0.4

3.2 ± 0.6

2.8 ± 0.5

 

GH

1.3 ± 0.2

1.1 ± 0.6

1.8 ± 0.5

1.3 ± 0.9

1.5 ± 0.7

1.6 ± 0.6

SVR

CON

24.8 ± 0.9

26.9 ± 4.1

29.6 ± 8.6

29.3 ± 6.5

24.3 ± 7.1

27.6 ± 3.2

(dyn*s/cm^5)

CH

27.2 ± 5.2

26.0 ± 7.3

18.3 ± 3.5

19.2 ± 2.7

19.5 ± 2.0

19.8 ± 2.3*

 

GH

21.9 ± 3.7

16.0 ± 2.6

15.5 ± 1.7

16.4 ± 2.9

15.9 ± 2.8

17.3 ± 2.8*

CPP

CON

53 ± 10

68 ± 14

74 ± 3

71 ± 4

72 ± 6

74 ± 3

(mmHg)

CH

63 ± 12

60 ± 5

45 ± 6

53 ± 4

51 ± 7

52 ± 2*#

 

GH

70 ± 5

74 ± 4

68 ± 6

70 ± 3

66 ± 5

67 ± 3

  1. *p < 0.1 compared to CON, # p < 0.05 GH compared to CH