Measures | Groups | Baseline | 30 min | 60 min | 90 min | 120 min | Mean ± SEM at all time points |
---|---|---|---|---|---|---|---|
HR | CON | 116 ± 5 | 118 ± 14 | 134 ± 19 | 122 ± 22 | 124 ± 9 | 119 ± 15 |
(bpm) | CH | 111 ± 4 | 116 ± 12 | 107 ± 5 | 117 ± 10 | 124 ± 9 | 114 ± 10 |
 | GH | 90 ± 6 | 111 ± 12 | 98 ± 11 | 101 ± 13 | 103 ± 9 | 111 ± 15 |
MAP | CON | 65 ± 6 | 78 ± 12 | 85 ± 1 | 82 ± 2 | 83 ± 8 | 86 ± 4 |
(mmHg) | CH | 84 ± 11 | 82 ± 6 | 67 ± 6 | 74 ± 4 | 73 ± 6 | 73 ± 2* |
 | GH | 81 ± 3 | 80 ± 2 | 77 ± 3 | 79 ± 2 | 77 ± 2 | 78 ± 3 |
PAP | CON | 15 ± 1 | 14 ± 3 | 15 ± 1 | 14 ± 2 | 15 ± 1 | 15 ± 2 |
(mmHg) | CH | 22 ± 4 | 22 ± 2 | 20 ± 2 | 23 ± 1 | 25 ± 1 | 23 ± 1* |
 | GH | 22 ± 2 | 28 ± 2 | 24 ± 2 | 29 ± 3 | 29 ± 3 | 27 ± 2* |
Pwedge | CON | 11.7 ± 0.6 | 12.0 ± 0.6 | 11.7 ± 0.7 | 12.3 ± 1.2 | 12.3 ± 0.9 | 12.5 ± 0.9 |
(mmHg) | CH | 14.2 ± 0.9 | 13.2 ± 0.8 | 13.0 ± 0.5 | 12.3 ± 0.9 | 12.5 ± 0.9 | 12.7 ± 0.5 |
 | GH | 15.8 ± 1.3 | 15.0 ± 1.2 | 13.8 ± 1.3 | 14.8 ± 0.3 | 15.0 ± 0.4 | 14.4 ± 0.7 |
CO | CON | 2.6 ± 0.3 | 3.1 ± 0.8 | 3.3 ± 0.7 | 3.2 ± 0.9 | 3.7 ± 0.6 | 3.8 ± 0.5 |
(L/min) | CH | 4.3 ± 1.2 | 4.3 ± 1.0 | 4.1 ± 0.7 | 4.1 ± 0.4 | 3.8 ± 0.3 | 3.9 ± 0.3 |
 | GH | 3.9 ± 0.4 | 5.4 ± 1.0 | 5.1 ± 0.4 | 5.2 ± 0.7 | 5.1 ± 0.7 | 5.2 ± 0.4*# |
ICP | CON | 12 ± 3 | 10 ± 2 | 11 ± 2 | 11 ± 3 | 11 ± 3 | 14 ± 2 |
(mmHg) | CH | 21 ± 3 | 22 ± 3 | 21 ± 2 | 21 ± 3 | 22 ± 3 | 17 ± 1 |
 | GH | 11 ± 2 | 7 ± 2 | 10 ± 4 | 9 ± 3 | 11 ± 5 | 13 ± 2 |
SV | CON | 23.3 ± 3.4 | 29.3 ± 11.5 | 26.8 ± 8.3 | 28.6 ± 9.5 | 34.1 ± 9.9 | 35.4 ± 4.3 |
(mL) | CH | 40.8 ± 12.4 | 39.9 ± 8.7 | 39.7 ± 7.3 | 35.9 ± 3.5 | 31.7 ± 3.1 | 35.7 ± 2.9 |
 | GH | 44.8 ± 6.1 | 48.2 ± 3.9 | 53.2 ± 4.3 | 52.7 ± 7.0 | 50.2 ± 5.7 | 48.4 ± 3.6*# |
PVR | CON | 1.7 ± 0.9 | 3.1 ± 0.8 | 1.5 ± 0.4 | 2.6 ± 0.7 | 2.5 ± 0.5 | 2.4 ± 0.7 |
(dyn*s/cm^5) | CH | 2.1 ± 0.5 | 3.6 ± 1.9 | 2.1 ± 0.6 | 2.6 ± 0.4 | 3.2 ± 0.6 | 2.8 ± 0.5 |
 | GH | 1.3 ± 0.2 | 1.1 ± 0.6 | 1.8 ± 0.5 | 1.3 ± 0.9 | 1.5 ± 0.7 | 1.6 ± 0.6 |
SVR | CON | 24.8 ± 0.9 | 26.9 ± 4.1 | 29.6 ± 8.6 | 29.3 ± 6.5 | 24.3 ± 7.1 | 27.6 ± 3.2 |
(dyn*s/cm^5) | CH | 27.2 ± 5.2 | 26.0 ± 7.3 | 18.3 ± 3.5 | 19.2 ± 2.7 | 19.5 ± 2.0 | 19.8 ± 2.3* |
 | GH | 21.9 ± 3.7 | 16.0 ± 2.6 | 15.5 ± 1.7 | 16.4 ± 2.9 | 15.9 ± 2.8 | 17.3 ± 2.8* |
CPP | CON | 53 ± 10 | 68 ± 14 | 74 ± 3 | 71 ± 4 | 72 ± 6 | 74 ± 3 |
(mmHg) | CH | 63 ± 12 | 60 ± 5 | 45 ± 6 | 53 ± 4 | 51 ± 7 | 52 ± 2*# |
 | GH | 70 ± 5 | 74 ± 4 | 68 ± 6 | 70 ± 3 | 66 ± 5 | 67 ± 3 |