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Table 1 Baseline demographic, haemodynamics, plasma and renal variables in conscious lambs

From: Renal effects of angiotensin II in the newborn period: role of type 1 and type 2 receptors

 

One week

Six weeks

Animal characteristics

  

Sample size, n

8

10

Sex

3♀/5♂

7♀/3♂

Age, days

8 (1)

41 (1)*

Kidney weight, g

62.9 (15.1)

80.6 (7.7)*

Baseline haemodynamics

  

MAP, mmHg

72 (7)

77 (5)*

RBF, mL · g−1 · min−1

1.7 (0.6)

4.0 (1.6)*

RVR, mmHg · g−1 · min−1

44.7 (16.6)

19.1 (7.2)*

Baseline renal variables

  

RPF, mL · g−1 · min−1

1.07 (0.33)

5.60 (2.01)*

GFR, mL · g−1 · min−1

0.39 (0.16)

0.37 (0.20)

FF, %

39.2 (22.8)

18.24 (11.6)*

V, μL · g−1 · min−1

4.6 (1.5)

4.9 (3.4)

CH2O, μL · g−1 · min−1

−3.7 (2.8)

−8.3 (5.2)*

POsm, mOsm/kgH2O

303 (9)

301 (8)

UOsm, mOsm/kgH2O

627 (201)

835 (289)*

COsm, μL · g−1 · min−1

7.9 (3.4)

10.6 (3.5)*

Plasma concentrations

  

PNa, mmol · L−1

143.2 (5.5)

144.8 (9.3)

PK, mmol · L−1

3.5 (0.3)

3.7 (0.4)

PCl, mmol · L−1

65.4 (2.4)

64.7 (3.5)

Urinary excretion rates

  

UNaV, μmol · g−1 · min−1

0.05 (0.06)

0.05 (0.03)

UKV, μmol · g−1 · min−1

0.51 (0.26)

0.84 (0.23)*

UClV, μmol · g−1 · min−1

0.13 (0.12)

0.16 (0.11)

UNa/UK

0.07 (0.05)

0.08 (0.05)

TTKG

17.8 (6.9)

16.7 (3.1)

Renal clearances

  

CNa, μL · g−1 · min−1

0.2 (0.1)

1.1 (0.6)*

CCl, μL · g−1 · min−1

2.0 (1.9)

2.4 (1.4)

CK, mL−1 · min−1

0.15 (0.1)

0.63 (0.3)*

  1. Values are presented as mean  (SD). *p < 0.05 six weeks compared with one week
  2. MAP mean arterial pressure, RBF renal blood flow, RVR renal vascular resistance, GFR glomerular filtration rate, RPF renal plasma flow, FF filtration fraction, V urinary flow rate, PX plasma concentration of electrolyte X, UXV urinary excretion rate of electrolyte X, CX clearance of electrolyte X, UNa/UK urine Na+ to K+ ratio, TTKG transtubular K+ gradient, UOsm urinary osmolality, COsm clearance of osmoles, CH 2 O free water clearance