Table 1 Baseline demographic, haemodynamics, plasma and renal variables in conscious lambs
From: Renal effects of angiotensin II in the newborn period: role of type 1 and type 2 receptors
| One week | Six weeks | |
|---|---|---|
| Animal characteristics | ||
| Sample size, n | 8 | 10 |
| Sex | 3♀/5♂ | 7♀/3♂ |
| Age, days | 8 (1) | 41 (1)* |
| Kidney weight, g | 62.9 (15.1) | 80.6 (7.7)* |
| Baseline haemodynamics | ||
| MAP, mmHg | 72 (7) | 77 (5)* |
| RBF, mL · g−1 · min−1 | 1.7 (0.6) | 4.0 (1.6)* |
| RVR, mmHg · g−1 · min−1 | 44.7 (16.6) | 19.1 (7.2)* |
| Baseline renal variables | ||
| RPF, mL · g−1 · min−1 | 1.07 (0.33) | 5.60 (2.01)* |
| GFR, mL · g−1 · min−1 | 0.39 (0.16) | 0.37 (0.20) |
| FF, % | 39.2 (22.8) | 18.24 (11.6)* |
| V, μL · g−1 · min−1 | 4.6 (1.5) | 4.9 (3.4) |
| CH2O, μL · g−1 · min−1 | −3.7 (2.8) | −8.3 (5.2)* |
| POsm, mOsm/kgH2O | 303 (9) | 301 (8) |
| UOsm, mOsm/kgH2O | 627 (201) | 835 (289)* |
| COsm, μL · g−1 · min−1 | 7.9 (3.4) | 10.6 (3.5)* |
| Plasma concentrations | ||
| PNa, mmol · L−1 | 143.2 (5.5) | 144.8 (9.3) |
| PK, mmol · L−1 | 3.5 (0.3) | 3.7 (0.4) |
| PCl, mmol · L−1 | 65.4 (2.4) | 64.7 (3.5) |
| Urinary excretion rates | ||
| UNaV, μmol · g−1 · min−1 | 0.05 (0.06) | 0.05 (0.03) |
| UKV, μmol · g−1 · min−1 | 0.51 (0.26) | 0.84 (0.23)* |
| UClV, μmol · g−1 · min−1 | 0.13 (0.12) | 0.16 (0.11) |
| UNa/UK | 0.07 (0.05) | 0.08 (0.05) |
| TTKG | 17.8 (6.9) | 16.7 (3.1) |
| Renal clearances | ||
| CNa, μL · g−1 · min−1 | 0.2 (0.1) | 1.1 (0.6)* |
| CCl, μL · g−1 · min−1 | 2.0 (1.9) | 2.4 (1.4) |
| CK, mL−1 · min−1 | 0.15 (0.1) | 0.63 (0.3)* |