Fig. 4

Inhibition by amiloride analogs of strial H⁺ flux from stria vascularis. a Summary traces of perfusion of dimethylamiloride (DMA; 30 μM; N = 5); box shows the duration of the experimental period. b summary family of curves for four Na⁺,H⁺ exchanger inhibitors: HOE694 (N = 3–7), amiloride (N = 4–6), S3226 (N = 3–6) and DMA (N = 3–9). Data from DMA and S3226 were fitted with a dual Michaelis-Menton equation consisting of one component that contributes 18 % (putative apical NHEs) and a second component that contributes 82 % (putative metabolic pathway target) of the total response