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Table 3 Effect of age and diet on functional recovery during reperfusion after 15 min global ischaemia

From: Myocardial susceptibility to ischaemia/reperfusion in obesity: a re-evaluation of the effects of age

 

Coronary flow (ml/min)

Aortic flow (ml/min)

Cardiac output (ml/min)

Heart rate (beats/min)

PSP (mm Hg)

Total Work (mW)

Total work (% recovery)

22 Weeks

 Age-Matched Controls (6)

   a6/6

Before

18.5 ± 0.9

46.1 ± 1.7

64.6 ± 2.2

282 ± 9

100 ± 2

14.40 ± 0.50

 

After

15.5 ± 1.4

23.1 ± 3.2

38.7 ± 4.1

277 ± 9

90 ± 2

7.81 ± 0.90

53.1 ± 4.8

p

NS

0.005

0.0001

NS

0.0001

0.0001

 

 DIO (6)

   a6/6

Before

19.1 ± 1.2

43.2 ± 1.3

62.3 ± 2.1

285 ± 9

99 ± 1

13.80 ± 0.47

69.4 ± 3.0+

After

17.7 ± 0.8

28.4 ± 1.2

46.1 ± 1.5

272 ± 7

91 ± 1

9.38 ± 0.40

 

p

NS

0.0001

0.0001

NS

0.001

0.0001

 

p1

NS

NS

NS

NS

NS

NS

 

17 months

 Age-matched controls (6)

   a5/6

Before

19.0 ± 3

48.0 ± 3.0

67.0 ± 3.6

274 ± 11

101 ± 2

14.91 ± 0.9

 

After

19.0 ± 1

29.7 ± 8.1

48.7 ± 8.7

223 ± 47

80 ± 16

9.72 ± 2.47

66.8 ± 16.7

p

NS

0.041

NS

NS

NS

NS

 

p2

NS

NS

NS

NS

NS

NS

NS

 DIO (6)

   a3/6

Before

21.7 ± 1.7

36.3 ± 6.5

58.0 ± 6.5

258 ± 8

99 ± 2.5

12.84 ± 1.71

 

After

21.3 ± 1.7

18.0 ± 9.3

39.3 ± 9.4

107 ± 53

47 ± 21

6.21 ± 3.0

43.6 ± 20.1

p

NS

NS

NS

0.026

NS

NS

NS

p1

NS

NS

NS

0.05

NS

NS

NS

p3

0.049

NS

NS

0.001

0.0172

NS

NS

  1. p values indicate significance of difference between “before” and “after” values in each group; p1 values indicate significance of difference between “after” values of age-matched controls and DIO at 22 weeks and 17 months respectively; p2 values indicate significance of difference between “after” values of controls at 22 weeks and 17 months; p3 values indicate significance of difference between “after” values of DIO at 22 weeks and 17 months. a Number of hearts which produced aortic output during reperfusion. Number in brackets indicate number of rats. + p = 0.0086 vs 22 weeks age-matched controls