Table 4 Effect of ischaemic preconditioning on functional recovery during reperfusion after 35 min regional ischaemia in young (22 weeks) rats
From: Myocardial susceptibility to ischaemia/reperfusion in obesity: a re-evaluation of the effects of age
Coronary flow (ml/min) | Aortic flow (ml/min) | Cardiac output (ml/min) | Heart rate (beats/min) | PSP (mm Hg) | Total Work (mW) | Total work (% recovery) | ||
|---|---|---|---|---|---|---|---|---|
Age-matched controls | ||||||||
Non-preconditioned (6) | ||||||||
a3/6 | Before | 18.3 ± 0.6 | 39.7 ± 3.5 | 57.7 ± 3.8 | 259 ± 6 | 92 ± 2 | 11.86 ± 1.01 | |
After | 6.9 ± 3.1 | 8.7 ± 4.1 | 15.6 ± 7.1 | 127 ± 57 | 42. ± 19 | 2.64 ± 1.23 | 19.7 ± 9.4 | |
p | 0.0051 | 0.0002 | 0.0004 | 0.0422 | 0.0226 | 0.0002 | ||
Preconditioned (5) | ||||||||
a5/5 | Before | 20.8 ± 0.8 | 37.2 ± 1.2 | 58 ± 1.8 | 261 ± 22 | 91 ± 3 | 12.2 ± 0.64 | |
After | 15.2 ± 0.8 | 23.2 ± 2.3 | 38.4 ± 3.0 | 243 ± 17 | 83 ± 2 | 7.49 ± 0.86 | 60.8 ± 4.5 | |
p | 0.0046 | 0.0008 | 0.0009 | NS | 0.0072 | 0.0004 | ||
p1 | 0.0441 | 0.0166 | 0.0226 | NS | NS | 0.0124 | 0.0051 | |
DIO | ||||||||
Non-preconditioned (6) | ||||||||
a6/6 | Before | 17.3 ± 0.7 | 33.7 ± 0.5 | 51.0 ± 10.9 | 243 ± 8 | 92 ± 1 | 10.48 ± 0.32 | |
After | 10.4 ± 1 | 9.2 ± 1.6 | 19.5 ± 1.7 | 246 ± 9 | 84 ± 1.9 | 3.67 ± 0.38 | 34.8 ± 2.99 | |
p | 0.0002 | 0.0001 | 0.0001 | NS | 0.0134 | 0.0001 | ||
Preconditioned (5) | ||||||||
a4/5 | Before | 20.8 ± 1.5 | 37.6 ± 3.0 | 58.4 ± 3.7 | 255 ± 6 | 94 ± 4 | 12.3 ± 0.89 | |
After | 15.2 ± 4.0 | 20.0 ± 5.2 | 35.2 ± 8.9 | 211 ± 53 | 71 ± 18 | 7.07 ± 1.78 | 54 ± 13 | |
p | NS | NS | 0.0056 | NS | NS | 0.0091 | ||
p2 | NS | NS | NS | NS | NS | NS | NS | |