Table 5 Effect of ischaemic preconditioning on functional recovery during reperfusion after 35 min regional ischaemia in middle-aged (17 months) rats
From: Myocardial susceptibility to ischaemia/reperfusion in obesity: a re-evaluation of the effects of age
Coronary flow (ml/min) | Aortic flow (ml/min) | Cardiac output (ml/min) | Heart rate (beats/min) | PSP (mm Hg) | Total Work (mW) | Total work (% recovery) | ||
|---|---|---|---|---|---|---|---|---|
Age-matched controls | ||||||||
Non-preconditioned (8) | ||||||||
a7/8 | Before | 20.5 ± 1.5 | 45.0 ± 1.4 | 65.5 ± 2.0 | 235 ± 11 | 104 ± 1 | 15.02 ± 0.5 | |
After | 22.1 ± 2.4 | 13.6 ± 4.9 | 35.8 ± 6.3 | 236 ± 37 | 77 ± 11 | 6.58 ± 1.58 | 42.4 ± 9.2 | |
p | NS | 0.0001 | 0.0005 | NS | 0.0409 | 0.0003 | ||
Preconditioned (6) | ||||||||
a2/6 | Before | 18.5 ± 2.9 | 26.8 ± 5.5 | 45.3 ± 7.3 | 216 ± 27 | 104 ± 7 | 10.29 ± 1.62 | |
After | 12.0 ± 5.6 | 6.0 ± 4.1 | 18.0 ± 8.8 | 164 ± 56 | 51 ± 17 | 3.38 ± 1.78 | 28.4 ± 12.1 | |
P | NS | 0.0123 | 0.0372 | NS | 0.0163 | 0.0168 | ||
p1 | NS | NS | NS | NS | NS | NS | NS | |
DIO | ||||||||
Non-preconditioned (9) | ||||||||
a8/9 | Before | 19.0 ± 2.1 | 37.6 ± 3.4 | 56.6 ± 4 | 253 ± 17 | 100 ± 3 | 12.62 ± 1.12 | |
After | 22.3 ± 2.6 | 7.2 ± 1.8 | 29.6 ± 3.2 | 211 ± 34 | 77 ± 10 | 5.24 ± 0.86 | 41.8 ± 6.6 | |
p | NS | 0.0001 | 0.0003 | NS | 0.0375 | 0.0005 | ||
Preconditioned (6) | ||||||||
a1/6 | Before | 17.8 ± 1.64 | 26.2 ± 5.6 | 44.0 ± 6.6 | 232 ± 32 | 108 ± 9 | 10.43 ± 1.8 | |
After | 15.0 ± 4.8 | 0 | 15.0 ± 4.8 | 164 ± 53 | 45 ± 15 | 1.81 ± 0.26 | 21.6 ± 7.9 | |
p | NS | 0.0009 | 0.0056 | NS | 0.0065 | 0.0011 | ||
p2 | NS | 0.0078 | 0.0218 | NS | NS | 0.0114 | NS | |