Skip to main content
Fig. 4 | BMC Physiology

Fig. 4

From: Short-term overfeeding of zebrafish with normal or high-fat diet as a model for the development of metabolically healthy versus unhealthy obesity

Fig. 4

Diet-induced obesity is accompanied by characteristic alterations in AT and liver marker genes. Expression of marker genes for lipid metabolism (pparg, fabp11a, fasn, srebf1, atgl, hsl, lpl), inflammation (il1b, tnfa) and fibrosis (col1a1a) was analyzed in visceral AT (a) and liver (b) after 8-week overfeeding of adult male zebrafish with NFD or HFD. Induction of obesity by NFD-OF and HFD-OF resulted in characteristic alterations in metabolic, inflammatory and fibrotic marker gene expression in visceral AT and liver of zebrafish. Data show results from 3 independent feeding experiments and are given as mean ± SEM. Statistical analyses was performed by One-Way ANOVA and Bonferroni post-test and significant p-values are indicated. *, p < 0.05; AT, adipose tissue; NFD, normal fat diet; HFD, high fat diet; OF, overfeeding

Back to article page