Fig. 5
From: Adiponectin is required for maintaining normal body temperature in a cold environment
Adiponectin ablation reduces thermogenic activity in subcutaneous fat. Subcutaneous (inguinal) fat from10-month old WT and Adipoq −/− mice was collected after 6 h following 4 °C cold exposure. aSubcutaneous fat weight and percentage ratio compared to body weight (BW). b Expression of thermogenic genes. c Immunohistochemical images of the UCP-1 and Mitomarker in inguinal fat. Scale bar is 50 μm. d Expression of mitochondrial dynamic genes. e Representative Western blots of AMPK activation in inguinal fat of WT and Adipoq −/− mice. p-AMPK for phosphorylated AMPA; t-AMPK for total AMPK. f Expression of regulators potentially involved in adiponectin-mediated thermogenesis. n = 6. *P < 0.05, **P < 0.001 WT vs. Adipoq −/−