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Fig. 3 | BMC Physiology

Fig. 3

From: Regulation of Locomotor activity in fed, fasted, and food-restricted mice lacking tissue-type plasminogen activator

Fig. 3

Activity During LD – Baseline and Fasting. Representative actograms (a) of food restriction protocol in tPA−/− and tPA+/+ mice in LD. Arrows indicate onset and offset of fast and beginning of restricted feeding. Fast includes food removal at ZT 12 and return 48 h later at ZT 12. Average 24 h activity profile (b), bar indicates dark phase; locomotor activity is higher in tPA+/+ (n = 13) than tPA−/− (n = 14) at ZT 12-17 (p < 0.05). During fast day 1 total locomotor activity (c) is higher in tPA+/+ (n = 8) than tPA−/− (n = 7) (p < 0.05) with no effect of time of day. During fast day 2 (d) total locomotor activity is significantly higher in tPA−/− (n = 8) than tPA+/+ (n = 8) during both the night (ZT15-18) and the day (ZT 5-7, 9-10) (p < 0.001). Error bars represent standard error of the mean

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