Fig. 5
From: Deficiency of the BMP Type I receptor ALK3 partly protects mice from anemia of inflammation
Comparable BA-induced inflammation in Alk3fl/fl; Alb-Cre mice and Alk3fl/fl mice. a Granulocytes from Alk3fl/fl and Alk3fl/fl; Alb-Cre mice 14 days after heat-killed Brucella abortus (BA) or saline injection (*P = 0.01: Alk3fl/fl injected with saline [n = 4] vs Alk3fl/fl injected with BA [n = 4]; *P = 0.01: Alk3fl/fl; Alb-Cre injected with saline [n = 4] vs Alk3fl/fl; Alb-Cre injected with BA [n = 6]), and (b) Relative hepatic IL-6 mRNA levels from Alk3fl/fl and Alk3fl/fl; Alb-Cre mice 14 days after BA administration (*P = 0.03: Alk3fl/fl injected with saline [n = 3] vs Alk3fl/fl injected with BA [n = 5]; **P = 0.01: Alk3fl/fl; Alb-Cre injected with saline [n = 4] vs Alk3fl/fl; Alb-Cre injected with BA [n = 6]). c Relative hepatic TNF-α mRNA levels (*P = 0.04: Alk3fl/fl injected with saline [n = 3] vs Alk3fl/fl injected with BA [n = 4]; *P = 0.01: Alk3fl/fl; Alb-Cre injected with saline [n = 5] vs Alk3fl/fl; Alb-Cre injected with BA [n = 6]). d Relative hepatic HO-1 mRNA levels (*P = 0.01: Alk3fl/fl injected with saline [n = 4] vs Alk3fl/fl injected with BA [n = 6]; *P = 0.01: Alk3fl/fl; Alb-Cre injected with saline [n = 4] vs Alk3fl/fl; Alb-Cre injected with BA [n = 6])