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  1. Myocardial hypoxic-ischemic injury is the cause of significant morbidity and mortality worldwide. The cardiomyocyte response to hypoxic-ischemic injury is known to include changes in cell cycle regulators. The...

    Authors: Sheila A Haley, Ting Zhao, Lijun Zou, Jan E Klysik, James F Padbury and Lazaros K Kochilas
    Citation: BMC Physiology 2008 8:4
    Content type: Research article Published on:

  2. The aim of this study was to analyze the effects of transition out of and into daylight saving time on the rest-activity cycles and sleep. Rest-activity cycles of nine healthy participants aged 20 to 40 years ...

    Authors: Tuuli A Lahti, Sami Leppämäki, Jouko Lönnqvist and Timo Partonen
    Citation: BMC Physiology 2008 8:3
    Content type: Research article Published on:

  4. Wound healing in horses is fraught with complications. Specifically, wounds on horse limbs often develop exuberant granulation tissue which behaves clinically like a benign tumor and resembles the human keloid...

    Authors: Vincenzo Miragliotta, Zoë Ipiña, Josiane Lefebvre-Lavoie, Jacques G Lussier and Christine L Theoret
    Citation: BMC Physiology 2008 8:1
    Content type: Research article Published on:

  5. Tumor necrosis factor alpha (TNFα) is implicated in a wide variety of pathological and physiological processes, including chronic inflammatory conditions, coronary artery disease, diabetes, obesity, and cachex...

    Authors: Michael D Hayward, Beverly K Jones, Arman Saparov, Heather S Hain, Anne-Cecile Trillat, Michelle M Bunzel, Aaron Corona, Bifang Li-Wang, Bryan Strenkowski, Caroline Giordano, Hai Shen, Emily Arcamone, Jeffrey Weidlick, Maria Vilensky, Marina Tugusheva, Roland H Felkner…
    Citation: BMC Physiology 2007 7:13
    Content type: Research article Published on:

  6. The aim of this work was to study how evenly detoxifying genes are transcribed spatially in liver tissue of fish. Ten Atlantic salmon Salmo salar were intraperitoneally injected with 50 mg/kg of the strong CYP1A ...

    Authors: Pål A Olsvik, Kai K Lie, Øystein Sæle and Monica Sanden
    Citation: BMC Physiology 2007 7:12
    Content type: Research article Published on:

  8. MAdCAM-1 plays a central role in T-lymphocyte homing to the gut, but its role in chronic liver inflammation remains unknown. Therefore, this study measured MAdCAM-1 expression, regulation, and function in cult...

    Authors: Tomoaki Ando, Robert R Langley, Yuping Wang, Paul A Jordan, Alireza Minagar, J Steven Alexander and Merilyn H Jennings
    Citation: BMC Physiology 2007 7:10
    Content type: Research article Published on:

  9. Exogenous NGF or saline was delivered to the detrusor smooth muscle of female rats for a two-week period using osmotic mini-pumps. We then determined: (1) bladder function using conscious cystometry; (2) organ...

    Authors: Peter Zvara and Margaret A Vizzard
    Citation: BMC Physiology 2007 7:9
    Content type: Research article Published on:

  10. Butyrate is the main nutrient for the colonocytes but the effect of the fraction reaching the liver is not totally known. A decrease in tissue ATP content and increase in respiration was previously demonstrate...

    Authors: Jean-Louis Gallis, Pierre Tissier, Henri Gin and Marie-Christine Beauvieux
    Citation: BMC Physiology 2007 7:8
    Content type: Research article Published on:

  11. We have previously reported that a Teiid lizard red blood cells (RBCs) such as Ameiva ameiva and Tupinambis merianae controls intracellular calcium levels by displaying multiple mechanisms. In these cells, calciu...

    Authors: Flávio H Beraldo and Célia RS Garcia
    Citation: BMC Physiology 2007 7:7
    Content type: Research article Published on:

  12. Prolactin promotes proliferation of several cells. Prolactin receptor exists as two isoforms: long and short, which activate different transduction pathways including the Ca2+-dependent PKC-signaling. No informat...

    Authors: Silvia Taffetani, Shannon Glaser, Heather Francis, Sharon DeMorrow, Yoshiyuki Ueno, Domenico Alvaro, Luca Marucci, Marco Marzioni, Giammarco Fava, Julie Venter, Shelley Vaculin, Bradley Vaculin, Ian Pak-Yan Lam, Vien Hoi-Yi Lee, Eugenio Gaudio, Guido Carpino…
    Citation: BMC Physiology 2007 7:6
    Content type: Research article Published on:

  13. It has been reported that Toll-like receptor 4 (TLR4) deficiency reduces infarct size after myocardial ischemia/reperfusion (MI/R). However, measurement of MI/R injury was limited and did not include cardiac func...

    Authors: Se-Chan Kim, Alexander Ghanem, Heidi Stapel, Klaus Tiemann, Pascal Knuefermann, Andreas Hoeft, Rainer Meyer, Christian Grohé, Anne A Knowlton and Georg Baumgarten
    Citation: BMC Physiology 2007 7:5
    Content type: Research article Published on:

  14. In general, inflammation plays a role in most bladder pathologies and represents a defense reaction to injury that often times is two edged. In particular, bladder neurogenic inflammation involves the particip...

    Authors: Ricardo Saban, Michael R D'Andrea, Patricia Andrade-Gordon, Claudia K Derian, Igor Dozmorov, Michael A Ihnat, Robert E Hurst, Carole A Davis, Cindy Simpson and Marcia R Saban
    Citation: BMC Physiology 2007 7:4
    Content type: Research article Published on:

  15. Protease-activated receptors (PAR) are present in the urinary bladder, and their expression is altered in response to inflammation. PARs are a unique class of G protein-coupled that carry their own ligands, wh...

    Authors: Ricardo Saban, Michael R D'Andrea, Patricia Andrade-Gordon, Claudia K Derian, Igor Dozmorov, Michael A Ihnat, Robert E Hurst, Cindy Simpson and Marcia R Saban
    Citation: BMC Physiology 2007 7:3
    Content type: Research article Published on:

  16. Insulin-like growth factor-I (IGF-I) plays a crucial role in wound healing and tissue repair. We tested the hypotheses that systemic administration of IGF-I, or growth hormone (GH), or both (GH+IGF-I) would im...

    Authors: Paolo P Provenzano, Adriana L Alejandro-Osorio, Kelley W Grorud, Daniel A Martinez, Arthur C Vailas, Richard E Grindeland and Ray Vanderby Jr
    Citation: BMC Physiology 2007 7:2
    Content type: Research article Published on:

  17. Ethidium homodimer is a cell-membrane impermeant nuclear fluorochrome that has been widely used to identify necrotic cells in culture. Here, we describe a novel technique for evaluating necrosis of epithelial ...

    Authors: Joshua R Edwards, Evangelos A Diamantakos, Jacob D Peuler, Peter C Lamar and Walter C Prozialeck
    Citation: BMC Physiology 2007 7:1
    Content type: Research article Published on:

  19. Breathing in humans is dually controlled for metabolic (brainstem commands) and behavioral purposes (suprapontine commands) with reciprocal modulation through spinal integration. Whereas the ventilatory respon...

    Authors: Chrystèle Locher, Mathieu Raux, Marie-Noelle Fiamma, Capucine Morélot-Panzini, Marc Zelter, Jean-Philippe Derenne, Thomas Similowski and Christian Straus
    Citation: BMC Physiology 2006 6:7
    Content type: Research article Published on:

  22. Diabetes is associated with declining sexual function in women. However, the effects of diabetes on genital tissue structure, innervation and function remains poorly characterized. In control and streptozotoci...

    Authors: Noel N Kim, Miljan Stankovic, Tulay T Cushman, Irwin Goldstein, Ricardo Munarriz and Abdulmaged M Traish
    Citation: BMC Physiology 2006 6:4
    Content type: Research article Published on:

  24. The tight junction is a dynamic structure that is regulated by a number of cellular signaling processes. Occludin, claudin-1, claudin-2 and claudin-3 are integral membrane proteins found in the tight junction ...

    Authors: David M Patrick, Amanda K Leone, Jeffry J Shellenberger, Kara A Dudowicz and Jonathan M King
    Citation: BMC Physiology 2006 6:2
    Content type: Research article Published on:

  25. An organ such as the bladder consists of complex, interacting set of tissues and cells. Inflammation has been implicated in every major disease of the bladder, including cancer, interstitial cystitis, and infe...

    Authors: Marcia R Saban, Helen L Hellmich, Mary Turner, Ngoc-Bich Nguyen, Rajanikanth Vadigepalli, David W Dyer, Robert E Hurst, Michael Centola and Ricardo Saban
    Citation: BMC Physiology 2006 6:1
    Content type: Research article Published on:

  26. The genome sequence of the pufferfish Takifugu rubripes is an enormously useful tool in the molecular physiology of fish. Euryhaline fish that can survive both in freshwater (FW) and seawater (SW) are also very u...

    Authors: Akira Kato, Hiroyuki Doi, Tsutomu Nakada, Harumi Sakai and Shigehisa Hirose
    Citation: BMC Physiology 2005 5:18
    Content type: Research article Published on:

  27. The aim of the study was to evaluate the acute and continuous (up to 14 days of treatment) effect of growth hormone (GH) on blood pressure (BP) regulation and to investigate the interplay between GH, nitric ox...

    Authors: Henrik C Nyström, Natalia Klintland, Kenneth Caidahl, Göran Bergström and Anna Wickman
    Citation: BMC Physiology 2005 5:17
    Content type: Research article Published on:

  28. Nitroglycerin can induce relaxation of swine carotid artery without sustained reductions in [Ca2+]i or myosin regulatory light chain (MRLC) phosphorylation. This has been termed force suppression and been found t...

    Authors: Timothy W Batts, John S Walker, Richard A Murphy and Christopher M Rembold
    Citation: BMC Physiology 2005 5:16
    Content type: Research article Published on:

  29. Ciliary neurotrophic factor (CNTF) is important for neuronal and muscle development, and genetic variation in the CNTF gene has been associated with muscle strength. The effect of CNTF on nerve development sug...

    Authors: Robin A Conwit, Shari Ling, Stephen Roth, Daniel Stashuk, Ben Hurley, Robert Ferrell and E Jeffrey Metter
    Citation: BMC Physiology 2005 5:15
    Content type: Research article Published on:

  30. The importance of apoptosis in the injury sustained by the human myocardium during ischaemia and reoxygenation and the underlying mechanisms remain unclear. To quantify apoptosis and necrosis induced by simula...

    Authors: Hunaid A Vohra and Manuel Galiñanes
    Citation: BMC Physiology 2005 5:14
    Content type: Research article Published on:

  31. Recent data suggest that canalicular bile secretion involves selective expression and coordinated regulation of aquaporins (AQPs), a family of water channels proteins. In order to further characterize the role...

    Authors: Sergio A Gradilone, Pamela S Tietz, Patrick L Splinter, Raúl A Marinelli and Nicholas F LaRusso
    Citation: BMC Physiology 2005 5:13
    Content type: Research article Published on:

  34. Many in vitro studies have shown that adenosine (Ado) can induce vascular endothelial growth factor (VEGF) mRNA and protein expression and stimulate endothelial proliferation. In the present study, we seek to det...

    Authors: Thomas H Adair, Reid Cotten, Jian-Wei Gu, Janelle S Pryor, Kenneth R Bennett, Michael R McMullan, Preston McDonnell and Jean-Pierre Montani
    Citation: BMC Physiology 2005 5:10
    Content type: Research article Published on:

  35. Norepinephrine (NE), a classic neurotransmitter in the sympathetic nervous system, induces vasoconstriction of canine isolated mesenteric vein that is accompanied by a sustained membrane depolarization. The me...

    Authors: Ilia A Yamboliev and Violeta N Mutafova-Yambolieva
    Citation: BMC Physiology 2005 5:9
    Content type: Research article Published on:

  36. Microarray analysis is attractive within the field of endocrine research because regulation of gene expression is a key mechanism whereby hormones exert their actions. Knowledge discovery and testing of hypoth...

    Authors: Nina Ståhlberg, Roxana Merino, Luis Henríquez Hernández, Leandro Fernández-Pérez, Albin Sandelin, Pär Engström, Petra Tollet-Egnell, Boris Lenhard and Amilcar Flores-Morales
    Citation: BMC Physiology 2005 5:8
    Content type: Research article Published on:

  38. Right ventricular hypertrophy (RVH) is an important complication of chronic lung disease. However, the signal transduction pathways involved as well as the physiological changes to the right ventricle have not...

    Authors: Erick Avelar, Thunder Jalili, Li Dong, Joel Arvizo, Ping Hu, Sheldon E Litwin and John P Mattson
    Citation: BMC Physiology 2005 5:6
    Content type: Research article Published on:

  39. Chronic fatigue syndrome (CFS) is defined by debilitating fatigue that is exacerbated by physical or mental exertion. To search for markers of CFS-associated post-exertional fatigue, we measured peripheral blo...

    Authors: Toni Whistler, James F Jones, Elizabeth R Unger and Suzanne D Vernon
    Citation: BMC Physiology 2005 5:5
    Content type: Research article Published on:

  40. In this study, we examined the correlation between excitation-contraction coupling characteristics and skeletal muscle fibre type by (1) localizing the distribution of dihydropyridine receptor (DHPR) protein a...

    Authors: Satu Mänttäri and Matti Järvilehto
    Citation: BMC Physiology 2005 5:4
    Content type: Research article Published on:

  41. Cytokine mediated induction of the mucosal addressin cell adhesion molecule-1(MAdCAM-1) expression is associated with the onset and progression of inflammatory bowel disease (IBD).

    Authors: Makoto Sasaki, Paul Jordan, Tomas Welbourne, Alireza Minagar, Takashi Joh, Makoto Itoh, John W Elrod and J Steven Alexander
    Citation: BMC Physiology 2005 5:3
    Content type: Research article Published on:

  42. It is well known that cytotoxic factors, such as lipopolysaccharides, derange nitrogen metabolism in hepatocytes and nitric oxide (NO) is involved among the other factors regulating this metabolic pathway. Hep...

    Authors: Settimio Sesti, Guglielmo Martino, Sergio Mazzulla and Rosa Chimenti
    Citation: BMC Physiology 2005 5:2
    Content type: Research article Published on:

  43. Electrophysiological data suggest that cardiac KATP channels consist of Kir6.2 and SUR2A subunits, but the distribution of these (and other KATP channel subunits) is poorly defined. We examined the localization o...

    Authors: Alison Morrissey, Erika Rosner, Jennifer Lanning, Lavanya Parachuru, Piyali Dhar Chowdhury, Sandra Han, Gwendolyn Lopez, XiaoYong Tong, Hidetada Yoshida, Tomoe Y Nakamura, Michael Artman, Jonathan P Giblin, Andrew Tinker and William A Coetzee
    Citation: BMC Physiology 2005 5:1
    Content type: Research article Published on:

  44. Lipoprotein lipase (LPL) is anchored at the vascular endothelium through interaction with heparan sulfate. It is not known how this enzyme is turned over but it has been suggested that it is slowly released in...

    Authors: Lucyna Neuger, Senén Vilaró, Carmen Lopez-Iglesias, Jitendra Gupta, Thomas Olivecrona and Gunilla Olivecrona
    Citation: BMC Physiology 2004 4:13
    Content type: Research article Published on:

  45. Seasonality of ovulatory activity is observed in European sheep and goat breeds, whereas tropical breeds show almost continuous ovulatory activity. It is not known if these tropical breeds are sensitive or not...

    Authors: Philippe Chemineau, Agnès Daveau, Yves Cognié, Gilles Aumont and Didier Chesneau
    Citation: BMC Physiology 2004 4:12
    Content type: Research article Published on:

  46. The understanding of bicarbonate kinetics and CO2 retention in the body is necessary to conduct amino acid tracer oxidation studies in both humans and laboratory animals. Significant metabolic activity is associa...

    Authors: Soenke Moehn, Robert FP Bertolo, Paul B Pencharz and Ronald O Ball
    Citation: BMC Physiology 2004 4:11
    Content type: Research article Published on:

  47. The classical cadherins such as E- and N-cadherin are Ca2+-dependent cell adhesion molecules that play important roles in the development and maintenance of renal epithelial polarity. Recent studies have shown th...

    Authors: Walter C Prozialeck, Peter C Lamar and Denah M Appelt
    Citation: BMC Physiology 2004 4:10
    Content type: Research article Published on:

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