Figure 13
From: VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG
Effects of instillation of BCG, VEGF 165 , and VEGF 121 into the urinary bladder resulted in alterations of vascular plasticity. (A) Microvessel density (MVD) was determined by computing the area occupied by CD31+ blood vessels that was expressed as percent of the cross-sectional area. (B) Angiogenesis was defined by the proliferation of CD31+ blood vessels. For this purpose, the expression of a marker of proliferation (KI67) was calculated taking CD31+ blood vessels as region of interest (ROI).