Fatigue-inducing stimulation resolves myotonia in a drug-induced model

BMC Physiology

Table 1 The outset of repetitive stimulation during 20 Hz and 50 Hz stimulation.

Stimulation Measurement	Frequency Stimulation	Before Krebs	After Krebs	Before 9-AC	After 9-AC
Peak force (% of initial)	20 Hz	138 ± 8	142 ± 10	155 ± 21	315 ± 53*
	50 Hz	319 ± 65	345 ± 91	293 ± 47	356 ± 58
Contraction time (ms)	20 Hz	23.7 ± 2.3	23.8 ± 1.2	23.2 ± 2.8	44.8 ± 6.7*
	50 Hz	20.1 ± 0.9	20.6 ± 1.3	20.0 ± 0.7	20.7 ± 1.2
Half relaxation time (ms)	20 Hz	26.0 ± 4.4	26.5 ± 1.7	29.2 ± 5.0	883.5 ± 296.0*
	50 Hz	26.4 ± 1.6	27.9 ± 2.6	28.6 ± 3.2	421.7 ± 308.3*
Late relaxation time (ms)	20 Hz	45.5 ± 11.8	51.4 ± 10.4	73.6 ± 50.8	1324.4 ± 339.2*
	50 Hz	32.0 ± 6.0	34.5 ± 3.9	28.6 ± 8.0	1142.6 ± 504.9*

The effect of Kreb's solution and 9-AC on diaphragm muscle at the outset of repetitive stimulation on peak force, contraction time, half relaxation time, and late relaxation time during 20 Hz and 50 Hz stimulation. Values are means ± SD. Asterisks indicate significant differences between before and after 9-AC data.

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