Figure 5
From: Non-endothelial endothelin counteracts hypoxic vasodilation in porcine large coronary arteries
Effect of the potassium channel blocker TEA on hypoxic vasodilation. (A) Concentration-response curves for O2 lowering in the absence and the presence of an inhibitor of soluble guanylyl cyclase, ODQ (3 × 10-6 M) and the absence or presence of the potassium channel blocker TEA (10 μM). (B) Concentration-response curves for NO in the absence and the presence of an inhibitor of soluble guanylyl cyclase, ODQ (3 × 10-6 M) and the absence or presence of the potassium channel blocker TEA (10 μM). Results are means ± SEM of 8 experiments. Differences were evaluated with two-way ANOVA with Bonferroni post-test: * P < 0.05, ** P < 0.01, ***P < 0.001 compared to control.