Figure 7

WT-CFTR function is not affected by the null CFTR allele in the Cincinnati WT-CFTR/Null mice. A. Nasal Potential Difference Assays (NPD) were performed on the three genotypes of the mice: WT/WT, WT/null, and null/null. NPD recordings were measured for each genotype in the presence of normal Ringer’s solution, low Cl- ringer’s solution, and then low Cl- Ringer’s solution containing the cAMP agonist salbutamol (100 μM) and adenosine (100 μM). B. Summary data of the results illustrated in A. C. Scatterplot which represents the NPD response of each mouse to low Cl- and cAMP agonists segregated to genotype.