Contractile properties and movement behaviour in neonatal rats with axotomy, treated with the NMDA antagonist DAP5

Petsanis, Konstantinos; Chatzisotiriou, Athanasios; Kapoukranidou, Dorothea; Simeonidou, Constantina; Kouvelas, Dimitrios; Albani, Maria

doi:10.1186/1472-6793-12-5

Table 5 Locomotor tests

From: Contractile properties and movement behaviour in neonatal rats with axotomy, treated with the NMDA antagonist DAP5

	AGE	PROCEDURE				ANOVA ON THE RANKS
		CONTROL	CRUSH	DAP5	CRUSH-DAP5	P-VALUE
Rotarod (sec)	P14	264.20 ± 12.28	8.40 ± 2.70*	256.00 ± 12.02	19.00 ± 3.39 ^#	0.001
	P21	289.80 ± 14.94	20.40 ± 6.50^*	276.40 ± 16.02	51.40 ± 7.86^#	0.001
	P28	289.20 ± 11.80	37.20 ± 9.15^*	290.60 ± 12.92	104.20 ± 9.98^#	0.001
	ADULT	285.80 ± 13.57	45.80 ± 7.98^*	289.40 ± 15.03	229.80 ± 12.34^#	0.001
Bridge 1 cm	P14	1.20 ± 0.45	8.60 ± 0.55^*	1.00 ± 0.71	4.20 ± 0.84^#	0.001
	P21	0.80 ± 0.84	7.40 ± 0.89^*	0.60 ± 0.55	2.60 ± 1.52	0.003
	P28	0.80 ± 0.84	7.20 ± 0.84^*	1.00 ± 0.71	2.80 ± 0.45^#	0.001
	ADULT	0.80 ± 0.45	6.20 ± 1.10^*	0.80 ± 0.45	3.00 ± 0.71^#	0.001
Bridge 3 cm	P14	0.80 ± 0.84	7.60 ± 0.89^*	0.60 ± 0.55	2.80 ± 0.84^#	0.001
	P21	0.40 ± 0.89	7.00 ± 0.71^*	0.40 ± 0.55	2.80 ± 0.84^#	0.001
	P28	0.60 ± 0.55	5.80 ± 1.30^*	0.60 ± 0.89	2.20 ± 0.84^#	0.002
	ADULT	0.20 ± 0.45	5.00 ± 1.58^*	0.60 ± 0.55	2.20 ± 0.84^#	0.001
Bridge 5 cm	P14	0.60 ± 0.55	6.20 ± 0.45^*	0.00 ± 0.00	2.40 ± 0.55^#	0.001
	P21	0.40 ± 0.55	4.40 ± 1.14^*	0.40 ± 0.55	1.60 ± 1.14	0.004
	P28	0.40 ± 0.55	4.40 ± 1.14^*	0.20 ± 0.45	2.00 ± 1.00^#	0.001
	ADULT	0.00 ± 0.00	2.80 ± 0.84^*	0.20 ± 0.45	1.80 ± 0.84^*	0.001
Gait 1 cm	P14	2.80 ± 0.84	4.60 ± 0.89^*	2.60 ± 1.14	3.40 ± 0.89	0.037
(errors)	P21	2.40 ± 1.14	4.60 ± 0.55^*	2.20 ± 1.48	3.00 ± 0.71	0.016
	P28	2.80 ± 0.84	3.80 ± 0.84	2.40 ± 1.14	2.60 ± 0.89	0.149
	ADULT	2.40 ± 1.14	4.00 ± 1.00	2.00 ± 1.58	2.00 ± 1.22	0.091
Gait 3 cm	P14	2.40 ± 0.89	4.00 ± 0.71^*	2.20 ± 0.84	2.80 ± 1.10	0.025
(errors)	P21	1.80 ± 0.84	3.80 ± 0.84^*	1.80 ± 1.30	1.80 ± 1.30	0.036
	P28	1.80 ± 1.48	4.20 ± 0.84^*	1.60 ± 0.89	2.00 ± 0.00	0.014
	ADULT	1.80 ± 1.30	3.80 ± 1.30	1.60 ± 1.14	1.80 ± 1.30	0.094
Gait 5 cm	P14	2.40 ± 1.52	3.40 ± 0.55	1.60 ± 1.14	3.00 ± 1.00	0.098
(errors)	P21	1.40 ± 1.14	3.00 ± 0.71^*	0.80 ± 0.84	1.40 ± 0.55	0.019
	P28	1.80 ± 1.48	3.60 ± 0.89^*	1.80 ± 0.45	1.20 ± 1.30	0.029
	ADULT	1.20 ± 1.30	3.40 ± 1.52	1.20 ± 0.84	1.20 ± 0.84	0.089
Limb Rotation	P14	13.40 ± 0.98	0.00 ± 0.00	13.18 ± 0.76	14.42 ± 0.89	0.194
	P21	17.88 ± 0.44	21.24 ± 0.86^*	17.90 ± 0.53	20.00 ± 0.83^*	0.002
	P28	18.62 ± 1.21	22.56 ± 0.79^*	18.50 ± 0.86	22.12 ± 0.79^*	0.002
	ADULT	20.76 ± 1.87	27.28 ± 0.56^*	20.62 ± 1.64	24.60 ± 0.72^#	0.001
Stride Length (cm)	P14	3.78 ± 0.53	0.00 ± 0.00	3.70 ± 0.29	2.30 ± 0.51^*	0.010
	P21	11.86 ± 0.56	9.94 ± 0.44^*	12.02 ± 0.57	10.10 ± 0.70^*	0.003
	P28	15.78 ± 1.18	13.56 ± 0.41^*	15.42 ± 1.19	13.76 ± 0.60^*	0.006
	ADULT	17.82 ± 0.68	13.14 ± 0.95^*	18.02 ± 0.51	16.44 ± 0.54^#	0.001
DBF(cm)	P14	0.98 ± 0.18	0.00 ± 0.00	0.98 ± 0.22	0.64 ± 0.13^*	0.027
	P21	1.86 ± 0.18	1.30 ± 0.19^*	2.02 ± 0.20	1.36 ± 0.13^*	0.002
	P28	2.70 ± 0.19	2.96 ± 0.11	2.78 ± 0.16	2.20 ± 0.14^*	0.003
	ADULT	3.34 ± 0.23	3.80 ± 0.19^*	3.43 ± 0.19	2.92 ± 0.16^#	0.003

Values are expressed as Mean ± Standard deviation. Post-hoc multiple comparisons. *: different from control. ^#: different from crush. Level of significance was a = 0.05.

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