Drug-induced and postnatal hypothyroidism impairs the accumulation of diacylglycerol in liver and liver cell plasma membranes

Table 1 Blood serum thyroxine and triiodothyronine content in rats of different age and thyroid status

The T₄ and T₃ content in blood serum was determined by radioimmunoassay kits. The amount of thyroid hormones in serum was represented as nmol per liter. Treatment of the rats by mercazolil was performed as described in "Materials and Methods".T₄ (200 μg/100 g body weight) was injected to the normal rats three times a week. The last hormone injection was made 48 h prior to killing. Results are mean ± S.E. of 8 individual experiments. Here and in Table 2 and Figures 1,2,3,4,5 one experiment is equivalent to measurement of the parameters studied in a sample of serum or liver of a single animal. ^*p < 0.05 vs. 90-day-old rats, ^**p < 0.05 and ^*** p < 0.001 vs. control.

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