Table 1 Mean arterial blood pressure (MAP), urinary flow rate (UV) and urinary excretion of DA (UDAV), urinary excretion of DOPAC (UDacV) and norepinephrine (U NEV) in wild type and in heterozygous and homozygousCOMT gene deleted mice of the control groups. Kw = kidney weight. *p<0.05 vs WT (MAP) or vs WT and HT mice (UNEV).
From: Reduced natriuretic response to acute sodium loading in COMT Gene deleted mice
C1 | C2 | E1 | E2 | E3 | E4 | |
|---|---|---|---|---|---|---|
MAP (mmHg) | ||||||
Wild type | 89±2 | 88±2 | 85±2 | 83±2 | 80±2 | 80±7 |
Heterozygous | 90±3 | 88±3 | 86±3 | 82±3* | 80±2* | 83±2* |
Homozygous | 96±2 | 95±2 | 90±2 | 88±2 | 85±2* | 82±2* |
UV(μl·min -1 ·g -1 kw) | ||||||
Wild type | 1.82±0.30 | 1.87±0.20 | 1.84±0.21 | 2.29±0.25 | 2.64±0.31 | 2.69±0.57 |
Heterozygous | 2.18±0.24 | 1.83±0.13 | 2.05±0.11 | 2.43±0.19 | 2.76±0.25 | 2.66±0.44 |
Homozygous | 1.76±0.29 | 1.77±0.21 | 2.01±0.18 | 2.73±0.21 | 2.58±0.24 | 3.09±0.26 |
U DA V(ng·min -1 ·g -1 kw) | ||||||
Wild type | 3.17±0.67 | 4.31±0.80 | 3.62±0.81 | 3.91±0.86 | 3.77±0.78 | 3.80±1.67 |
Heterozygous | 4.51±0.94 | 4.18±0.94 | 4.01±0.93 | 3.99±0.86 | 3.86±0.83 | 6.13±1.95 |
Homozygous | 5.27±0.97 | 7.23±2.19 | 5.99±1.08 | 6.21±0.87 | 5.20±0.81 | 5.92±1.24 |
U Dac V (ng·min -1 ·g -1 kw) | ||||||
Wild type | 0.25±0.09 | 0.27±0.11 | 0.23±0.11 | 0.20±0.07 | 0.18±0.04 | 0.22±0.08 |
Heterozygous | 0.23±0.16 | 0.14±0.08 | 0.08±0.04 | 0.11±0.05 | 0.21±0.14 | 0.16±0.07 |
Homozygous | 0.30±0.19 | 0.33±0.19 | 0.35±0.24 | 0.31±0.21 | 0.29±0.21 | 0.54±0.41 |
U NE V (ng·min -1 ·g -1 kw) | ||||||
Wild type | 3.01±0.77 | 3.33±0.79 | 3.09±0.80 | 2.59±0.67 | 2.33±0.61 | 1.35±0.10 |
Heterozygous | 4.50±0.89 | 4.82±0.82 | 4.55±1.05 | 4.24±1.04 | 4.44±1.02 | 2.92±0.45 |
Homozygous | 7.44±1.60* | 8.12±1.72* | 7.25±1.28* | 7.45±1.29* | 7.43±0.96* | 8.53±0.47* |