Table 3 Mean arterial blood pressure (MAP), urinary flow rate (UV), urinary sodium (UNaV) and dopamine (UDA V) excretion in wild type, heterozygous and homozygous COMT gene deleted mice before (C1 and C2) and during (E1-E4) isotonic sodium loading. kw = kidney weight. *p < 0.05 vs C2 of the same genotype.
From: Reduced natriuretic response to acute sodium loading in COMT Gene deleted mice
C1 | C2 | E1 | E2 | E3 | E4 | |
|---|---|---|---|---|---|---|
MAP (mmHg) | ||||||
Wild type | 97±3 | 95±3 | 91±3 | 86±3* | 84±3* | 90±4* |
Heterozygous | 93±2 | 90±2 | 86±1 | 81±1* | 79±1* | 76±3* |
Homozygous | 94±1 | 93±2 | 86±2 | 81±2* | 77±2* | 74±2* |
UV (μl·min -1 ·g -1 kw | ||||||
Wild type | 1.90±0.18 | 1.99±0.28 | 2.26±0.30 | 3.34±0.34 | 5.66±0.89* | 6.94±1.33* |
Heterozygous | 1.88±0.18 | 1.96±0.18 | 2.38±0.26 | 2.56±0.25 | 3.62±0.37 | 4.53±0.48 |
Homozygous | 2.27±0.39 | 2.17±0.40 | 2.68±0.45 | 3.24±0.79 | 4.77±0.98* | 6.53±1.40* |
U Na V (μmol·min -1 ·g -1 kw) | ||||||
Wild type | 0.08 ± 0.02 | 0.07 ± 0.02 | 0.07 ± 0.01 | 0.14 ± 0.05* | 0.39 ± 0.16* | 0.87 ± 0.28* |
Heterozygous | 0.07 ± 0.01 | 0.08 ± 0.02 | 0.08 ± 0.01 | 0.07 ± 0.01 | 0.12 ± 0.04 | 0.25 ± 0.11 |
Homozygous | 0.09 ± 0.02 | 0.05 ± 0.01 | 0.05 ± 0.01 | 0.06 ± 0.02 | 0.14 ± 0.06 | 0.34 ± 0.13 |
U DA V (ng·min -1 ·g -1 kw | ||||||
Wild type | 3.2 ± 0.5 | 3.4 ± 0.5 | 3.7 ± 0.6 | 4.4 ± 0.7 | 5.6 ± 1.1* | |
Heterozygous | 3.4 ± 0.6 | 3.6 ± 0.5 | 3.7 ± 0.6 | 3.4 ± 0.5 | 3.8 ± 0.5 | |
Homozygous | 9.2 ± 2.8 | 8.5 ± 2.3 | 8.3 ± 2.5 | 6.7 ± 1.7 | 8.0 ± 2.6 |