Figure 5

2APB and xestospongin C have no effect on the EFS-induced slow membrane depolarization of canine isolated mesenteric vein. Intracellular recordings of membrane potential in response to EFS (0.1 ms, 13 V, 10 s, 0.5 Hz) in canine isolated mesenteric veins preincubated for 60 min prior to and throughout the experiment with 50 μM 2APB (A) or 30 μM xestospongin C (B). The experimental data are presented as mean ± SEM, n = 3–4 (C). Scale bars apply to traces A and B.