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Figure 5 | BMC Physiology

Figure 5

From: Inflammatory cytokines induce MAdCAM-1 in murine hepatic endothelial cells and mediate alpha-4 beta-7 integrin dependent lymphocyte endothelial adhesion In Vitro

Figure 5

Effect of nitric oxide (NO) donors and N-acetylcysteine, an antioxidant on MAdCAM-1 expression by HEC in response to TNF-α. HEC were pretreated for 30 minutes with the NO donors, DETA-NO or SperNO (500 uM), or L-NAME (1 mM), or N-acetylcysteine (1 mM). Tumor necrosis factor (TNF)-α (20 ng/ml) was then added to these cultures for 48 h. MAdCAM-1 expression was significantly increased by TNF-α and significantly reduced by DETA-NO, SperNO or NAC, but not by L-NAME. Values represent the mean ± SE; n = 3 experiments in each group. * = p < 0.01 vs. TNF-α treatment.

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BMC Physiology

ISSN: 1472-6793

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