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Figure 6 | BMC Physiology

Figure 6

From: Epigenetic and phenotypic changes result from a continuous pre and post natal dietary exposure to phytoestrogens in an experimental population of mice

Figure 6

Methylation profiles of the analyzed region of the Acta1 promoter in pancreas from offspring generated in the control or ISF group. DNA methylation gender differences are not observed in the population maintained on (a), control diet (P = 0.93), or on (b) ISF diet (P = 0.837). Nevertheless, pooling male and female data together shows a nearly significant difference due to the ISF treatment (P = 0.08), in which CpG site specific changes were detected in sites 5 (P = 0.004) and 8 (P = 0.045), as seen in (c), indicated with *. Using only control animals (both males and females) we found that methylation is increased in liver regarding to pancreas (P = 0.007), which shows the occurrence of tissue specific differences in DNA methylation for Acta1, as seen in (d).

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BMC Physiology

ISSN: 1472-6793

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