Table 2 Comparison of Ca²⁺ handling properties of E-C coupling in the developed model and experiments

Diastolic [Ca²⁺]_i (μM)

0.10

0.100 ± 0.012 [66]; 0.099 ± 0.011 [21]; 0.200 ± 0.021 [20]

Systolic [Ca²⁺]_i (μM)

0.46

0.458 ± 0.073 [66]; 0.314 ± 0.028 [21]; 0.425 ± 0.026 [20]

Decay constant of Ca²⁺ transient (ms)

190

166 ± 12 (0.25 Hz) [66]; 293 ± 19 [20];

188 ± 14 (0.5 Hz) [19]; 210 (0.5 Hz) [2]

∫I_{Ca, L} dt (μM)

1.0

1.5 [22]

Maximum J_REL (μmol/Lcytosol/ms)

2.2

3 (rat) [72, 81]

Diastolic SR Ca²⁺ content (μM)

92

142 ± 9 [20]; 102 (0.5 Hz) [19]; 64.3 ± 13.0 (0.5 Hz) [73]

Fractional release (%)

28

29 ± 3 [20]

SERCA Ca²⁺ removal fraction (%)

89

88 [20]; 90.3 (0.5 Hz) [19]; 88 (0.5 Hz) [73]

NCX Ca²⁺ removal fraction (%)

10

12 [20]; 9.2 (0.5 Hz) [19]; 12 (0.5 Hz) [73]

Slow Ca²⁺ removal fraction (%)

0.56

0.5 (0.5 Hz) [19]

FDAR (τ_{1 Hz}/τ_{4 Hz})

2.36

2.06 ± 0.08 (τ_{0.5 Hz}/τ_{4 Hz}) [20]; 1.87 ± 0.06 (τ_{1 Hz}/τ_{5 Hz}) [74]