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Figure 4 | BMC Physiology

Figure 4

From: Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure

Figure 4

ISO treatment induces fibrosis but not apoptosis in mouse hearts. H&E stained sections of the left ventricle of a representative sedentary (A), ISO-treated (B), and exercised (C) mouse are shown. Similar sections were stained with Masson trichrome to assess fibrosis in sedentary (D), ISO-treated (E), and exercised (F) mouse hearts. TUNEL staining indicated that there was no detectable apoptosis in these same hearts. A positive control (mouse thymus) for TUNEL staining is shown in panel G, and representative ISO-treated and exercised mouse hearts (left ventricles) are shown in panels H and I, respectively. TUNEL staining of sedentary mouse hearts was similar to ISO-treated and exercised mice (no apoptosis detected; data not shown). Black scale bar = 120 μm.

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BMC Physiology

ISSN: 1472-6793

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