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Table 6 Genes altered in human pathological cardiac hypertrophy that are recapitulated in animal models

From: Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure

Gene

Human

Animal Models

 

AS

Cong

Idiop

Isch

Drug

RQ

AB

MI

Sh

Salt

Exercise

 

Pathological

Phys

Adhesion and migration

ITGBL1

  

1.9

2.7

2.4

 

1.8

    

LTBP2

  

1.6

2.4

3.3

 

2.0

13.0

   

OMD

  

1.8

2.4

2.6

  

5.1

   

SERPINE2

2.6

  

1.5

 

1.8

1.7

2.8

   

THBS4

1.7

  

2.2

 

2.8

1.9

1.8

 

1.5

 

Cardiovascular functions

AOC3

  

1.5

1.6

2.2

      

APP

  

2.0

1.9

 

3.6

1.5

  

1.7

-1.6

ATP1A1

  

-1.7

-1.6

-1.9

d

 

+/-

 

2.3

-5.3

CCL2

  

-2.9

-2.7

3.7

 

1.9

3.7

  

-2.3

CTGF

2.2

  

1.5

3.7

2.0

2.4

3.1

  

-3.6

EGFR

  

-1.8

-1.5

2.9

 

-2.2

    

FN1

1.9

 

-1.6

-1.6

2.3

1.9

2.3

1.9

 

1.6

-1.7

M GCLM

  

-2.1

-1.6

3.0

  

1.6

   

GSK3B

  

-2.2

-1.7

     

-1.6

1.8

SERPINE1

  

-3.4

-3.6

1.6

 

1.8

3.4

 

1.9

 

SLC7A1

  

-2.0

-1.8

  

-1.6

-6.0

   

TGM2

  

-1.7

-1.7

1.9

 

1.5

   

-2.1

TIMP1

  

-1.9

-1.6

4.8

3.8

2.3

5.4

 

1.5

1.5

TIMP2

  

1.6

1.9

  

1.7

1.5

  

2.3

Cell growth/proliferation and survival

ACOX1

 

-1.6

 

2.1

  

-1.7

-5.5

 

1.7

-1.7

AMD1

 

-1.6

-2.0

-1.6

 

-2.6

-1.6

-1.6

   

CTSC

  

-2.4

-2.1

 

-2.0

5.7

4.0

 

2.0

-1.8

DDX3X

 

-1.6

-1.6

   

-2.6

   

2.5

KLF9

 

-2.0

-1.7

    

-3.9

 

-2.3

-1.6

OSMR

  

-1.9

-1.5

3.6

 

1.5

    

PAPSS2

  

-1.8

-1.6

1.8

 

-1.5

   

1.5

PXDN

  

1.6

2.2

 

1.8

1.7

    

SULF1

  

1.7

2.2

  

1.9

    

TFRC

  

-1.6

-1.7

-12.3

10.0

   

1.7

-2.8

Extracellular matrix morphology

ASPN

  

2.2

4.1

2.6

1.6

2.4

1.8

   

COL14A1

  

2.4

4.5

  

3.0

6.6

   

COL3A1

  

1.5

2.1

 

2.1

2.2

3.5

1.7

-4.5

-2.2

FBLN2

  

1.6

1.6

1.7

1.5

1.9

3.2

   

LUM

  

2.9

3.0

  

1.9

1.7

 

-2.2

 

MATN2

  

1.8

2.6

  

2.1

    

Immune response/modulation, inflammation, and stress response

DNAJA4

  

-2.4

-2.2

  

1.6

2.0

 

2.6

-2.9

FKBP4

  

-1.6

-1.5

-2.6

 

-1.6

-7.2

 

-2.0

-2.0

IFIT2

  

1.6

1.7

 

2.7

1.7

    

IFIT3

  

1.7

1.8

  

1.7

1.9

   

MGST1

  

-2.3

-2.4

2.0

    

2.0

 

Skeletal and muscular functions

CEBPD

  

-2.4

-2.0

6.7

 

1.5

2.2

  

-2.0

COL1A1

 

1.5

1.7

2.1

 

+/-

2.6

2.6

1.7

-2.4

-1.5

COL1A2

1.9

 

1.7

2.1

 

2.7

2.5

3.1

 

-2.1

-2.2

FRZB

  

2.1

2.7

 

i

1.8

9.0

   

HSPB6

2.3

1.9

       

2.0

 

IGFBP5

1.6

 

2.0

2.3

 

4.5

1.5

   

-0.5

KBTBD10

  

-2.3

-1.8

  

1.8

  

1.8

 

Tissue morphology

BCL6

 

-2.2

-1.9

  

+/-

-1.6

    

CFH

  

2.0

2.8

2.8

1.6

1.8

3.2

   

EGR1

  

-2.2

1.9

-3.3

 

0.1

 

1.8

1.6

-3.6

FLNC

 

1.5

-2.1

-1.8

  

1.6

  

1.6

-2.7

PRNP

 

-2.0

-1.6

   

1.7

  

2.2

 

TXNRD1

 

-1.5

-2.0

 

1.6

    

1.9

-1.8

Other or Unknown

ART3

 

-1.8

-1.6

   

-1.6

-9.5

  

1.7

CCDC80

  

1.6

2.1

2.1

 

1.7

2.8

  

-6.3

FNDC1

  

2.0

3.4

  

2.2

5.0

   

HMGB2

  

1.6

1.6

  

2.1

3.0

   

ITIH5

  

1.6

2.0

  

2.2

    

KCND3

 

-1.8

-1.7

      

-1.7

 

LDB3

  

1.6

1.7

 

-1.9

 

11.0

 

1.6

1.8

LYPLA1

 

-2.1

-1.8

   

-2.9

   

0.3

SLC40A1

  

1.6

2.1

2.1

    

1.5

-1.7

SYNPO2L

  

1.6

2.0

  

2.2

    

TAF9B

  

-1.7

-1.5

  

-1.7

 

2.0

  
  1. FC = fold-change. Dash ("-") before number indicates down-regulation, compared to appropriate controls. A blank indicates that no significant alteration (fold change at least 1.5, p value ≤ 0.05) was observed. For PMAGE data, "i" and "d" indicate induction and down-regulation with 0 transcripts detected in either wild-type or αMHC403/+ mice, respectively. Where genes that were represented by more than one polony (analogous to a probe set) conflicted in direction (one or more up-regulated sequence tags and one or down-regulated sequence tags representing the same gene), "+/-" is used in place of a FC value. Idiop, Isch, AS, and Cong = idiopathic, ischemic, aortic stenosis, and congenital, respectively. "Drug" refers to angiotensin II, 3,5-diiodothyropropionic acid, or isoproterenol treatment. Sh, MI, and AB = shunt, myocardial infarction, and aortic banding, respectively. RQ = αMHC403/+ mice, representing familial cardiac hypertrophy. Phys = physiological. Gene functions were obtained from Ingenuity pathway analysis software, supplemented with information obtained from the NCBI and Stanford SOURCE search databases. Some genes perform more than one function, but are only listed under one category.
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BMC Physiology

ISSN: 1472-6793

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