Figure 1
From: Acetate transiently inhibits myocardial contraction by increasing mitochondrial calcium uptake
Acetate causes a transient decrease of fractional sarcomere shortening and an increase in diastolic sarcomere length in isolated mouse cardiac myocytes. (A) Representative recording of average sarcomere length assessed continuously throughout application and removal of normal Tyrode solution (NT) supplemented with 10 mM sodium acetate. Summary data from experiments as in A (n = 15), illustrating the effects of acetate on (B) fractional sarcomere shortening and (C) diastolic sarcomere length.