Figure 5
From: Acetate transiently inhibits myocardial contraction by increasing mitochondrial calcium uptake
Inhibition of mitochondrial Ca2+uptake with Ru-360 inhibits the effects of acetate on cell contraction. (A) Representative recording of average sarcomere length assessed continuously throughout application and removal of normal Tyrode solution (NT) supplemented with 10 mM sodium acetate in cells pretreated with 10 μM Ru-360 for 30–60 minutes and maintained in Ru-360 throughout the acetate exposure. Summary data from experiments as in A (n = 11) illustrate that pretreatment with Ru-360 markedly suppresses the effect of acetate on both (B) fractional shortening and (C) diastolic sarcomere length.