Table 2 Effect of age and diet on functional recovery during reperfusion after 35 min regional ischaemia
From: Myocardial susceptibility to ischaemia/reperfusion in obesity: a re-evaluation of the effects of age
Coronary flow (ml/min) | Aortic flow (ml/min) | Cardiac output (ml/min) | Heart rate (beats/min) | PSP (mm Hg) | Total Work (mW) | Total work (% recovery) | ||
|---|---|---|---|---|---|---|---|---|
Age 22 weeks | ||||||||
Age-matched controls (6) | ||||||||
a3/6 | Before | 18.3 ± 0.6 | 39.7 ± 3.5 | 57.7 ± 3.8 | 259 ± 6 | 92 ± 2 | 11.86 ± 1.01 | |
After | 6.9 ± 3.1 | 8.7 ± 4.1 | 15.6 ± 7.1 | 127 ± 57 | 42 ± 19 | 2.64 ± 1.23 | 19.7 ± 9.4 | |
p | 0.0051 | 0.0002 | 0.0004 | 0.0422 | 0.0226 | 0.0002 | ||
DIO (6) | ||||||||
a6/6 | Before | 17.3 ± 0.7 | 33.7 ± 0.8 | 51.0 ± 0.9 | 243 ± 8 | 92 ± 1 | 10.48 ± 0.32 | |
After | 10.4 ± 1.0 | 9.2 ± 1.6 | 19.5 ± 1.7 | 246 ± 9 | 84 ± 1.9 | 3.67 ± 0.38 | 34.8 ± 2.99b | |
P | 0.0002 | 0.0001 | 0.0001 | NS | 0.0134 | 0.0001 | ||
Age 17 months | ||||||||
Age-matched controls (8) | ||||||||
a5/8 | Before | 20.5 ± 1.5 | 45.0 ± 1.4 | 65.5 ± 2.0 | 235 ± 11 | 104 ± 1 | 15.02 ± 0.50 | |
After | 22.1 ± 2.4 | 13.6 ± 4.9 | 35.8 ± 6.3 | 236 ± 37 | 77 ± 11 | 6.58 ± 1.58 | 42.4 ± 9.2 | |
p | NS | 0.0001 | 0.0005 | NS | 0.0409 | 0.0003 | ||
p1 | 0.0021 | NS | NS | NS | NS | NS | NS | |
DIO (9) | ||||||||
a7/9 | Before | 19.0 ± 21 | 37.6 ± 3.4 | 56.6 ± 4.0 | 253 ± 17 | 100 ± 3 | 12.62 ± 1.12 | |
After | 22.3 ± 2.6 | 7.2 ± 1.8 | 29.6 ± 3.2 | 211 ± 34 | 77 ± 10 | 5.24 ± 0.86 | 41.76 ± 6.6b | |
p | NS | 0.0001 | 0.0003 | NS | 0.0375 | 0.0005 | ||
p2 | 0.0037 | NS | 0.0309 | NS | NS | NS | NS | |