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  1. The acute response to genotoxic carcinogens in rats is an important model for researching cancer initiation events. In this report we define the normal rat colonic epithelium by describing transcriptional even...

    Authors: Caroline A Kerr, Barney M Hines, Janet M Shaw, Robert Dunne, Lauren M Bragg, Julie Clarke, Trevor Lockett and Richard Head
    Citation: BMC Physiology 2013 13:2
    Content type: Research article Published on:

  2. Like humans, fish can be classified according to their athletic performance. Sustained exercise training of fish can improve growth and physical capacity, and recent results have documented improved disease re...

    Authors: Vicente Castro, Barbara Grisdale-Helland, Sven M Jørgensen, Jan Helgerud, Guy Claireaux, Anthony P Farrell, Aleksei Krasnov, Ståle J Helland and Harald Takle
    Citation: BMC Physiology 2013 13:1
    Content type: Research article Published on:

  3. This work tests the hypothesis that bladder instillation with vascular endothelial growth factor (VEGF) modulates sensory and motor nerve plasticity, and, consequently, bladder function and visceral sensitivity.

    Authors: Anna P Malykhina, Qi Lei, Chris S Erickson, Miles L Epstein, Marcia R Saban, Carole A Davis and Ricardo Saban
    Citation: BMC Physiology 2012 12:15
    Content type: Research article Published on:

  4. Lipoprotein lipase (LPL) hydrolyzes triglycerides in plasma lipoproteins and enables uptake of lipolysis products for energy production or storage in tissues. Our aim was to study the localization of LPL and i...

    Authors: Rakel Nyrén, Chuchun L Chang, Per Lindström, Anastasia Barmina, Evelina Vorrsjö, Yusuf Ali, Lisa Juntti-Berggren, André Bensadoun, Stephen G Young, Thomas Olivecrona and Gunilla Olivecrona
    Citation: BMC Physiology 2012 12:14
    Content type: Research article Published on:

  5. Lipoprotein lipase (LPL) hydrolyzes triglycerides in lipoproteins and makes fatty acids available for tissue metabolism. The activity of the enzyme is modulated in a tissue specific manner by interaction with ...

    Authors: Olessia Kroupa, Evelina Vorrsjö, Rinke Stienstra, Frits Mattijssen, Stefan K Nilsson, Valentina Sukonina, Sander Kersten, Gunilla Olivecrona and Thomas Olivecrona
    Citation: BMC Physiology 2012 12:13
    Content type: Research article Published on:

  6. Rescue or correction of CFTR function in native epithelia is the ultimate goal of CF therapeutics development. Wild-type (WT) CFTR introduction and replacement is also of particular interest. Such therapies ma...

    Authors: Torry A Tucker, James A Fortenberry, Akos Zsembery, Lisa M Schwiebert and Erik M Schwiebert
    Citation: BMC Physiology 2012 12:12
    Content type: Research article Published on:

  7. Regular exercises are commonly described as an important factor in health improvement, being directly related to contractile force development in cardiac cells.

    Authors: Luiz A O Rocha, Bernardo A Petriz, David H Borges, Ricardo J Oliveira, Rosangela V de Andrade, Gilberto B Domont, Rinaldo W Pereira and Octávio L Franco
    Citation: BMC Physiology 2012 12:11
    Content type: Research article Published on:

  8. In Gallus gallus, eggshell formation takes place daily in the hen uterus and requires large amounts of the ionic precursors for calcium carbonate (CaCO3). Both elements (Ca2+, HCO3-) are supplied by the blood via...

    Authors: Vincent Jonchère, Aurélien Brionne, Joël Gautron and Yves Nys
    Citation: BMC Physiology 2012 12:10
    Content type: Research article Published on:

  9. Electrophysiological studies of L-type Ca2+ channels in isolated vascular smooth muscle cells revealed that depolarization of these cells evoked a transient and a time-independent Ca2+ current. The sustained, non...

    Authors: Paul Fransen, Cor E Van Hove, Johanna van Langen, Dorien M Schrijvers, Wim Martinet, Guido R Y De Meyer and Hidde Bult
    Citation: BMC Physiology 2012 12:9
    Content type: Research article Published on:

  11. Observations in our laboratory provide evidence of vascular islands, defined as disconnected endothelial cell segments, in the adult microcirculation. The objective of this study was to determine if vascular i...

    Authors: Molly R Kelly-Goss, Erica R Winterer, Peter C Stapor, Ming Yang, Richard S Sweat, William B Stallcup, Geert W Schmid-Schönbein and Walter L Murfee
    Citation: BMC Physiology 2012 12:7
    Content type: Research article Published on:

  13. It is well known that axotomy in the neonatal period causes massive loss of motoneurons, which is reflected in the reduction of the number of motor units and the alteration in muscle properties. This type of n...

    Authors: Konstantinos Petsanis, Athanasios Chatzisotiriou, Dorothea Kapoukranidou, Constantina Simeonidou, Dimitrios Kouvelas and Maria Albani
    Citation: BMC Physiology 2012 12:5
    Content type: Research article Published on:

  14. The expansion of adipose tissue is linked to the development of its vasculature, which appears to have the potential to regulate the onset of obesity. However, at present, there are no studies highlighting the...

    Authors: Francisco José Tinahones, Leticia Coín-Aragüez, Maria Dolores Mayas, Eduardo Garcia-Fuentes, Carmen Hurtado-del-Pozo, Joan Vendrell, Fernando Cardona, Rosa-Maria Calvo, Maria-Jesus Obregon and Rajaa El Bekay
    Citation: BMC Physiology 2012 12:4
    Content type: Research article Published on:

  15. Cardiovascular toxicity is a major limiting factor in drug development and requires multiple cost-effective models to perform toxicological evaluation. Zebrafish is an excellent model for many developmental, t...

    Authors: Satish Srinivas Kitambi, Erik S Nilsson, Petra Sekyrova, Cristian Ibarra, Gilbert Nyah Tekeoh, Michael Andäng, Patrik Ernfors and Per Uhlén
    Citation: BMC Physiology 2012 12:3
    Content type: Methodology article Published on:

  16. Matrix metalloproteinases (MMPs) 2 and 9 are two gelatinase members which have been found elevated in exudative pleural effusions. In endothelial cells these MMPs increase paracellular permeability via the dis...

    Authors: Eleni Apostolidou, Efrosyni Paraskeva, Konstantinos Gourgoulianis, Paschalis-Adam Molyvdas and Chrissi Hatzoglou
    Citation: BMC Physiology 2012 12:2
    Content type: Research article Published on:

  17. The transcription factor c-myc regulates genes involved in hepatocyte growth, proliferation, metabolism, and differentiation. It has also been assigned roles in liver development and regeneration. In previous stu...

    Authors: Jennifer A Sanders, Christoph Schorl, Ajay Patel, John M Sedivy and Philip A Gruppuso
    Citation: BMC Physiology 2012 12:1
    Content type: Research article Published on:

  19. Sedentary lifestyle is associated with coronary artery disease but even shorter periods of physical inactivity may increase cardiovascular risk. Cystatin C is independently associated with cardiovascular disea...

    Authors: Karin Arinell, Kjeld Christensen, Stéphane Blanc, Anders Larsson and Ole Fröbert
    Citation: BMC Physiology 2011 11:17
    Content type: Research article Published on:

  20. This work tests the hypothesis that increased levels of vascular endothelial growth factor (VEGF) observed during bladder inflammation modulates nerve plasticity.

    Authors: Marcia R Saban, Carole A Davis, Antonio Avelino, Francisco Cruz, Julie Maier, Dale E Bjorling, Thomas J Sferra, Robert E Hurst and Ricardo Saban
    Citation: BMC Physiology 2011 11:16
    Content type: Research article Published on:

  21. Calcium sparks are ryanodine receptor mediated transient calcium signals that have been shown to hyperpolarize the membrane potential by activating large conductance calcium activated potassium (BK) channels i...

    Authors: Gayathri Krishnamoorthy, Keil Regehr, Samantha Berge, Elias Q Scherer and Philine Wangemann
    Citation: BMC Physiology 2011 11:15
    Content type: Research article Published on:

  22. Pigs are widely used as models for human physiological changes in intervention studies, because of the close resemblance between human and porcine physiology and the high degree of experimental control when us...

    Authors: Morten R Clausen, Kirstine L Christensen, Mette S Hedemann, Ying Liu, Stig Purup, Mette Schmidt, Henrik Callesen, Jan Stagsted and Hanne C Bertram
    Citation: BMC Physiology 2011 11:14
    Content type: Research article Published on:

  24. In recent years the interest on the relationship of gut hormones to bone processes has increased and represents one of the most interesting aspects in skeletal research. The proportion of bone mass to soft tis...

    Authors: Elda L Pacheco-Pantoja, Lakshminarayan R Ranganath, James A Gallagher, Peter JM Wilson and William D Fraser
    Citation: BMC Physiology 2011 11:12
    Content type: Research article Published on:

  25. Evolutionary theories of aging propose that longevity evolves as a competition between reproduction and somatic maintenance for a finite pool of resources. Reproduction is thought to shorten lifespan by deplet...

    Authors: Ana S DePina, Wendy B Iser, Sung-Soo Park, Stuart Maudsley, Mark A Wilson and Catherine A Wolkow
    Citation: BMC Physiology 2011 11:11
    Content type: Research article Published on:

  27. The infrarenal abdominal aorta exhibits increased disease susceptibility relative to other aortic regions. Allograft studies exchanging thoracic and abdominal segments showed that regional susceptibility is ma...

    Authors: John H Lillvis, Robert Erdman, Charles M Schworer, Alicia Golden, Kimberly Derr, Zoran Gatalica, Laura A Cox, Jianbin Shen, Richard S Vander Heide, Guy M Lenk, Leigh Hlavaty, Li Li, James R Elmore, David P Franklin, John L Gray, Robert P Garvin…
    Citation: BMC Physiology 2011 11:9
    Content type: Research article Published on:

  28. The systemic vascular response to hypoxia is vasodilation. However, reports suggest that the potent vasoconstrictor endothelin-1 (ET-1) is released from the vasculature during hypoxia. ET-1 is reported to augm...

    Authors: Elise R Hedegaard, Edgaras Stankevicius, Ulf Simonsen and Ole Fröbert
    Citation: BMC Physiology 2011 11:8
    Content type: Research article Published on:

  29. One of the hallmarks of Alzheimer's disease, and several other degenerative disorders such as Inclusion Body Myositis, is the abnormal accumulation of amyloid precursor protein (APP) and its proteolytic amyloi...

    Authors: Chul Kim, Sapeckshita Srivastava, Marian Rice, Tanja A Godenschwege, Brooke Bentley, Saranya Ravi, Shuang Shao, Craig T Woodard and Lawrence M Schwartz
    Citation: BMC Physiology 2011 11:7
    Content type: Research article Published on:

  30. A population of satellite cells exists in skeletal muscle. These cells are thought to be primarily responsible for postnatal muscle growth and injury-induced muscle regeneration. The Janus kinase/signal transd...

    Authors: Marissa K Trenerry, Paul A Della Gatta and David Cameron-Smith
    Citation: BMC Physiology 2011 11:6
    Content type: Research article Published on:

  32. Sodium absorption by Reissner's membrane is thought to contribute to the homeostasis of the volume of cochlear endolymph. It was previously shown that the absorptive transepithelial current was blocked by amil...

    Authors: Muneharu Yamazaki, Kyunghee X Kim and Daniel C Marcus
    Citation: BMC Physiology 2011 11:4
    Content type: Research article Published on:

  33. Horses and humans share a natural proclivity for athletic performance. In this respect, horses can be considered a reference species in studies designed to optimize physical training and disease prevention. In...

    Authors: Stefano Capomaccio, Katia Cappelli, Giacomo Spinsanti, Marzia Mencarelli, Michela Muscettola, Michela Felicetti, Andrea Verini Supplizi and Marco Bonifazi
    Citation: BMC Physiology 2011 11:3
    Content type: Research article Published on:

  34. Separation from mechanical ventilation is a difficult task, whereas conventional predictive indices have not been proven accurate enough, so far. A few studies have explored changes of breathing pattern variab...

    Authors: Vasilios E Papaioannou, Ioanna G Chouvarda, Nikos K Maglaveras and Ioannis A Pneumatikos
    Citation: BMC Physiology 2011 11:2
    Content type: Research article Published on:

  35. We and others have demonstrated previously that ghrelin receptor (GhrR) knock out (KO) mice fed a high fat diet (HFD) have increased insulin sensitivity and metabolic flexibility relative to WT littermates. A str...

    Authors: Yong Qi, Kenneth A Longo, Derek J Giuliana, Samantha Gagne, Tom McDonagh, Elizabeth Govek, Anna Nolan, Chaoseng Zou, Kristen Morgan, Jeffrey Hixon, Jeffrey O Saunders, Peter S DiStefano and Brad J Geddes
    Citation: BMC Physiology 2011 11:1
    Content type: Research article Published on:

  36. Fish farmed under high intensity aquaculture conditions are subjected to unnatural environments that may cause stress. Therefore awareness of how to maintain good health and welfare of farmed fish is important...

    Authors: Henrik Sundh, Bjørn Olav Kvamme, Frode Fridell, Rolf Erik Olsen, Tim Ellis, Geir Lasse Taranger and Kristina Sundell
    Citation: BMC Physiology 2010 10:22
    Content type: Research article Published on:

  37. Obesity is a multifactorial disorder influenced by genetic and environmental factors. Animal models of obesity are required to help us understand the signaling pathways underlying this condition. Zebrafish pos...

    Authors: Takehiko Oka, Yuhei Nishimura, Liqing Zang, Minoru Hirano, Yasuhito Shimada, Zhipeng Wang, Noriko Umemoto, Junya Kuroyanagi, Norihiro Nishimura and Toshio Tanaka
    Citation: BMC Physiology 2010 10:21
    Content type: Research article Published on:

  38. Obese patients display an exaggerated morbidity during sepsis. Since consumption of a western-style diet (WD) is a major factor for obesity in the United States, the purpose of the present study was to examine...

    Authors: Chantal A Rivera, LaTausha Gaskin, Georg Singer, Jeff Houghton and Monique Allman
    Citation: BMC Physiology 2010 10:20
    Content type: Research article Published on:

  39. It has been proposed that anatomical differences in human and great ape guts arose in response to species-specific diets and energy demands. To investigate functional genomic consequences of these differences,...

    Authors: Paul A Watkins, Ann B Moser, Cicely B Toomer, Steven J Steinberg, Hugo W Moser, Mazen W Karaman, Krishna Ramaswamy, Kimberly D Siegmund, D Rick Lee, John J Ely, Oliver A Ryder and Joseph G Hacia
    Citation: BMC Physiology 2010 10:19
    Content type: Research article Published on:

  40. Muscle disease associated with different etiologies has been shown to produce localized accumulations of amyloid and oxidative stress-related proteins that are more commonly associated with neurodegeneration i...

    Authors: Claudine L Bitel, Yicheng Feng, Nizar Souayah and Peter H Frederikse
    Citation: BMC Physiology 2010 10:18
    Content type: Research article Published on:

  41. In mammals, vasopressin (AVP) is released from magnocellular neurons of the hypothalamus when osmotic pressure exceeds a fixed set-point. AVP participates to the hydromineral homeostasis (HH) by controlling wa...

    Authors: Louis Nadeau, Danielle Arbour and Didier Mouginot
    Citation: BMC Physiology 2010 10:17
    Content type: Research article Published on:

  43. Nitric oxide (NO) is cardioprotective and a mediator of ischemic preconditioning (IP). Endothelial nitric oxide synthase (eNOS) is protective against myocardial ischemic injury and a component of IP but the ro...

    Authors: Anupama Barua, Nicholas B Standen and Manuel Galiñanes
    Citation: BMC Physiology 2010 10:15
    Content type: Research article Published on:

  44. The underlying cellular and molecular mechanisms that coordinate the physiological processes in digestion are complex, cryptic, and involve the integration of multiple cellular and organ systems. In all intest...

    Authors: Dennis R LaJeunesse, Brooke Johnson, Jason S Presnell, Kathleen Kay Catignas and Grzegorz Zapotoczny
    Citation: BMC Physiology 2010 10:14
    Content type: Research article Published on:

  45. Spinal disorders are a major cause of disability for humans and an important health problem for intensively farmed animals. Experiments have shown that vertebral deformities present a complex but comparable et...

    Authors: Elisabeth Ytteborg, Jacob Torgersen, Grete Baeverfjord and Harald Takle
    Citation: BMC Physiology 2010 10:13
    Content type: Research article Published on:

  46. Hyperthermia has been shown in a number of organisms to induce developmental defects as a result of changes in cell proliferation, differentiation and gene expression. In spite of this, salmon aquaculture comm...

    Authors: Elisabeth Ytteborg, Grete Baeverfjord, Jacob Torgersen, Kirsti Hjelde and Harald Takle
    Citation: BMC Physiology 2010 10:12
    Content type: Research article Published on:

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