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  1. Skeletal muscle prefers carbohydrate use to fatty acid (FA) use as exercise intensity increases. In contrast, skeletal muscle minimizes glucose use and relies more on FA during fasting. In mice deficient for F...

    Authors: Tatsuya Iso, Hikari Haruyama, Hiroaki Sunaga, Miki Matsui, Hiroki Matsui, Rina Tanaka, Yogi Umbarawan, Mas Rizky A. A. Syamsunarno, Tomoyuki Yokoyama and Masahiko Kurabayashi
    Citation: BMC Physiology 2019 19:1
    Content type: Research article Published on:

  2. Inflammatory stimuli induce the hepatic iron regulatory hormone hepcidin, which contributes to anaemia of inflammation (AI). Hepcidin expression is regulated by the bone morphogenetic protein (BMP) and the int...

    Authors: Inka Gallitz, Niklas Lofruthe, Lisa Traeger, Nicole Bäumer, Verena Hoerr, Cornelius Faber, Tanja Kuhlmann, Carsten Müller-Tidow and Andrea U. Steinbicker
    Citation: BMC Physiology 2018 18:3
    Content type: Research article Published on:

  3. Circadian rhythms of physiology and behavior are driven by a circadian clock located in the suprachiasmatic nucleus of the hypothalamus. This clock is synchronized to environmental day/night cycles by photic i...

    Authors: Jessica A. Krizo, Linley E. Moreland, Ashutosh Rastogi, Xiang Mou, Rebecca A. Prosser and Eric M. Mintz
    Citation: BMC Physiology 2018 18:2
    Content type: Research article Published on:

  5. Thermogenic impairment promotes obesity and insulin resistance. Adiponectin is an important regulator of energy homeostasis. While many beneficial metabolic effects of adiponectin resemble that of activated th...

    Authors: Qiong Wei, Jong Han Lee, Hongying Wang, Odelia Y. N. Bongmba, Chia-Shan Wu, Geetali Pradhan, Zilin Sun, Lindsey Chew, Mandeep Bajaj, Lawrence Chan, Robert S. Chapkin, Miao-Hsueh Chen and Yuxiang Sun
    Citation: BMC Physiology 2017 17:8
    Content type: Research article Published on:

  6. Previous studies show that androgens are involved in hypertrophy and excitability of cardiomyocytes and that their effects are mediated through their receptor. The aim of this study was to evaluate the presenc...

    Authors: Enrique Pedernera, María José Gómora, Iván Meneses, Marlon De Ita and Carmen Méndez
    Citation: BMC Physiology 2017 17:7
    Content type: Research article Published on:

  7. Bladder pain is a prominent symptom in several urological conditions (e.g. infection, painful bladder syndrome/interstitial cystitis, cancer). Understanding the mechanism of bladder pain is important, particul...

    Authors: Fei Ma, Dimitrios E. Kouzoukas, Katherine L. Meyer-Siegler, Karin N. Westlund, David E. Hunt and Pedro L. Vera
    Citation: BMC Physiology 2017 17:6
    Content type: Research article Published on:

  9. Obese individuals differ in their risk of developing metabolic and cardiovascular complications depending on fat distribution (subcutaneous versus visceral) and adipose tissue (AT) phenotype (hyperplasic versu...

    Authors: Kathrin Landgraf, Susanne Schuster, Andrej Meusel, Antje Garten, Thomas Riemer, Dorit Schleinitz, Wieland Kiess and Antje Körner
    Citation: BMC Physiology 2017 17:4
    Content type: Methodology article Published on:

  10. Reports on the effect of age and obesity on myocardial ischaemia/reperfusion (I/R) injury and ischaemic preconditioning are contradictory. The aim of this study was to re-evaluate the effects of age and diet-i...

    Authors: I. Webster, R. Salie, E. Marais, W.-J. Fan, G. Maarman, B. Huisamen and A. Lochner
    Citation: BMC Physiology 2017 17:3
    Content type: Research article Published on:

  11. In preparation for migration from freshwater to marine habitats, Atlantic salmon (Salmo salar L.) undergo smoltification, a transformation that includes the acquisition of hyposmoregulatory capacity. The growth h...

    Authors: Jason P. Breves, Chelsea K. Fujimoto, Silas K. Phipps-Costin, Ingibjörg E. Einarsdottir, Björn Thrandur Björnsson and Stephen D. McCormick
    Citation: BMC Physiology 2017 17:2
    Content type: Research article Published on:

  13. In many vascular smooth muscle cells (SMCs), ryanodine receptor-mediated Ca2+ sparks activate large-conductance Ca2+-activated K+ (BK) channels leading to lowered SMC [Ca2+]i and vasodilation. Here we investigate...

    Authors: Gayathri Krishnamoorthy, Katrin Reimann and Philine Wangemann
    Citation: BMC Physiology 2016 16:6
    Content type: Research article Published on:

  14. Trimester-specific reference ranges for T3, T4, and TSH need to be established in different communities. Neither Sudan nor other African countries have established trimester-specific reference ranges for TSH, ...

    Authors: Enaam T. Elhaj, Ishag Adam, Mohamed A. Ahmed and Mohamed F. Lutfi
    Citation: BMC Physiology 2016 16:5
    Content type: Research article Published on:

  15. Disturbance of acid–base balance in the inner ear is known to be associated with hearing loss in a number of conditions including genetic mutations and pharmacologic interventions. Several previous physiologic...

    Authors: Hiromitsu Miyazaki, Philine Wangemann and Daniel C. Marcus
    Citation: BMC Physiology 2016 17:1
    Content type: Research article Published on:

  16. In vitro isolated heart preparations are valuable tools for the study of cardiac anatomy and physiology, as well as for preclinical device testing. Such preparations afford investigators a high level of hemody...

    Authors: Ryan P. Goff, Brian T. Howard, Stephen G. Quallich, Tinen L. Iles and Paul A. Iaizzo
    Citation: BMC Physiology 2016 16:4
    Content type: Research article Published on:

  18. The cell type, cell status and specific localization of Prothymosin α (PTMA) within cells seemingly determine its function. PTMA undergoes 2 types of protease proteolytic modifications that are useful in eluci...

    Authors: Caroline Mwendwa Kijogi, Christopher Khayeka-Wandabwa, Keita Sasaki, Yoshimasa Tanaka, Hiroshi Kurosu, Hayato Matsunaga and Hiroshi Ueda
    Citation: BMC Physiology 2016 16:2
    Content type: Research article Published on:

  19. Veterinary cardiology, especially electrocardiography, has shown major advancements for all animal species. Consequently, the number of ovine species used as experimental animals has increased to date. Few stu...

    Authors: Karoline Koether, Carla Maria Vela Ulian, Maria Lucia Gomes Lourenço, Renato Souza Gonçalves, Mateus José Sudano, Raíssa Karolliny Salgueiro Cruz, Naiana da Silva Branchini, Angélica Alfonso and Simone Biagio Chiacchio
    Citation: BMC Physiology 2016 16:1
    Content type: Research article Published on:

  20. Iodine-based solutions have long been known to be effective in aiding the differentiation among soft tissues in both fundamental anatomical research and for clinical diagnoses. Recently the combination of this...

    Authors: Zhiheng Li, Julia A. Clarke, Richard A. Ketcham, Matthew W. Colbert and Fei Yan
    Citation: BMC Physiology 2015 15:5
    Content type: Methodology article Published on:

  21. Neurogenic pulmonary edema (NPE) is a non-cardiogenic form of pulmonary edema that can occur consequent to central neurologic insults including stroke, traumatic brain injury, and seizure. NPE is a public heal...

    Authors: Shadi Khademi, Melinda A. Frye, Kimberly M. Jeckel, Thies Schroeder, Eric Monnet, Dave C. Irwin, Patricia A. Cole, Christopher Bell, Benjamin F. Miller and Karyn L. Hamilton
    Citation: BMC Physiology 2015 15:4
    Content type: Research article Published on:

  22. There is increasing evidence that poor growth of preterm infants is a risk factor for poor long-term development, while the effects of early postnatal growth restriction are not well known. We utilized a rat m...

    Authors: Erica E. Alexeev, Bo Lönnerdal and Ian J. Griffin
    Citation: BMC Physiology 2015 15:3
    Content type: Research article Published on:

  23. Elevated blood pressure is an important global health problem, and in-utero under-nutrition may be an important factor in the pathogenesis of hypertension. In the present study, we tested the hypothesis that ante...

    Authors: Ravi Goyal, Jonathan Van-Wickle, Dipali Goyal and Lawrence D. Longo
    Citation: BMC Physiology 2015 15:2
    Content type: Research article Published on:

  24. Exercise is a non-pharmacologic agent widely used for hypertension control, where low intensity is often associated with blood pressure reduction. Maximal lactate steady state (MLSS) was recently identified in...

    Authors: Bernardo A Petriz, Jeeser A Almeida, Clarissa P C Gomes, Carlos Ernesto, Rinaldo W Pereira and Octavio L Franco
    Citation: BMC Physiology 2015 15:1
    Content type: Research article Published on:

  25. Heat illness is a debilitating and potentially life-threatening condition. Limited data are available to identify individuals with heat illness at greatest risk for organ damage. We recently described the tran...

    Authors: Danielle L Ippolito, John A Lewis, Chenggang Yu, Lisa R Leon and Jonathan D Stallings
    Citation: BMC Physiology 2014 14:14
    Content type: Research article Published on:

  26. The multi-meric calcium/calmodulin-dependent protein kinase II (CaMKII) is the main CaMK in skeletal muscle and its expression increases with endurance training. CaMK family members are implicated in contracti...

    Authors: Wouter Eilers, Richard T Jaspers, Arnold de Haan, Céline Ferrié, Paola Valdivieso and Martin Flück
    Citation: BMC Physiology 2014 14:7
    Content type: Research article Published on:

  28. There is a close relationship between cardiovascular disease and cardiac energy metabolism, and we have previously demonstrated that palmitate inhibits myocyte contraction by increasing Kv channel activity and de...

    Authors: James F Schooley, Aryan MA Namboodiri, Rachel T Cox, Rolf Bünger and Thomas P Flagg
    Citation: BMC Physiology 2014 14:12
    Content type: Research article Published on:

  29. Multiple cell types including trophoblasts, osteoclasts and myoblasts require somatic cell fusion events as part of their physiological functions. In Drosophila Melanogaster the paralogus type 1 transmembrane ...

    Authors: Peter Joseph Durcan, Johannes D Conradie, Mari Van deVyver and Kathryn Helen Myburgh
    Citation: BMC Physiology 2014 14:11
    Content type: Research article Published on:

  30. The physiological effects of white-nose syndrome (WNS) in hibernating bats and ultimate causes of mortality from infection with Pseudogymnoascus (formerly Geomyces) destructans are not fully understood. Increased...

    Authors: Michelle L Verant, Carol U Meteyer, John R Speakman, Paul M Cryan, Jeffrey M Lorch and David S Blehert
    Citation: BMC Physiology 2014 14:10
    Content type: Research article Published on:

  31. The Xenopus oocyte is a useful cell model to study Ca2+ homeostasis and cell cycle regulation, two highly interrelated processes. Here, we used antisense oligonucleotides to investigate the role in the oocyte of ...

    Authors: Barbara Serrano-Flores, Edith Garay, Francisco G Vázquez-Cuevas and Rogelio O Arellano
    Citation: BMC Physiology 2014 14:9
    Content type: Research article Published on:

  33. MAPK-activated protein kinase 2 (MK2) plays a pivotal role in the cell response to (inflammatory) stress. Among others, MK2 is known to be involved in the regulation of cytokine mRNA metabolism and regulation ...

    Authors: Benjamin Vandendriessche, An Goethals, Alba Simats, Evelien Van Hamme, Peter Brouckaert and Anje Cauwels
    Citation: BMC Physiology 2014 14:5
    Content type: Research article Published on:

  34. Maternal diet during pregnancy can modulate skeletal muscle development of the offspring. Previous studies in pigs have indicated that a fat supplemented diet during pregnancy can improve piglet outcome, howev...

    Authors: Hernan P Fainberg, Kayleigh L Almond, Dongfang Li, Cyril Rauch, Paul Bikker, Michael E Symonds and Alison Mostyn
    Citation: BMC Physiology 2014 14:6
    Content type: Research article Published on:

  35. Dysregulation of the autonomic nervous system is frequent in subjects with cardiovascular disease. The contribution of different forms of renovascular hypertension and the mechanisms contributing to autonomic ...

    Authors: Rainer U Pliquett, Sebastian Benkhoff, Oliver Jung and Ralf P Brandes
    Citation: BMC Physiology 2014 14:4
    Content type: Research article Published on:

  36. Genes that decline in expression with age and are thought to coordinate growth cessation have been identified in various organs, but their expression in skeletal muscle is unknown. Therefore, our objective was...

    Authors: Jennifer C Jones, Kellie A Kroscher and Anna C Dilger
    Citation: BMC Physiology 2014 14:3
    Content type: Research article Published on:

  37. Atlantic salmon aquaculture operations in the Northern hemisphere experience large seasonal fluctuations in seawater temperature. With summer temperatures often peaking around 18-20°C there is growing concern ...

    Authors: Sven Martin Jørgensen, Vicente Castro, Aleksei Krasnov, Jacob Torgersen, Gerrit Timmerhaus, Ernst Morten Hevrøy, Tom Johnny Hansen, Sissel Susort, Olav Breck and Harald Takle
    Citation: BMC Physiology 2014 14:2
    Content type: Research article Published on:

  38. KCNQx genes encode slowly activating-inactivating K+ channels, are linked to physiological signal transduction pathways, and mutations in them underlie diseases such as long QT syndrome (KCNQ 1), epilepsy in adul...

    Authors: Calvin Wu, Kanishk Sharma, Kyle Laster, Mohamed Hersi, Christina Torres, Thomas J Lukas and Ernest J Moore
    Citation: BMC Physiology 2014 14:1
    Content type: Research article Published on:

  39. Authors: Gabriella Marfe, Marco Tafani, Bruna Pucci, Carla Di Stefano, Manuela Indelicato, Angela Andreoli, Matteo Antonio Russo, Paola Sinibaldi-Salimei and Vincenzo Manzi
    Citation: BMC Physiology 2014 13:13
    Content type: Retraction Note Published on:

    The original article was published in BMC Physiology 2010 10:7

  41. Postprandial lipidemia is important in the development of coronary artery disease (CAD). Consumption of a meal high in monounsaturated fat was correlated with acute impairment of endothelial function. However,...

    Authors: Ping Yi, Jia Pang, Jonathan Steven Alexander and Chantal Rivera
    Citation: BMC Physiology 2013 13:12
    Content type: Research article Published on:

  42. The alkaline version of the single-cell gel (comet) assay is a useful method for quantifying DNA damage. Although some studies on chronic and acute effects of exercise on DNA damage measured by the comet assay...

    Authors: Bruno Cesar Pereira, José Rodrigo Pauli, LusâniaMaria Greggi Antunes, Ellen Cristini de Freitas, Mara Ribeiro de Almeida, Vinícius de Paula Venâncio, Eduardo Rochete Ropelle, Claudio Teodoro de Souza, Dennys Esper Cintra, Marcelo Papoti and AdelinoSanchez Ramos da Silva
    Citation: BMC Physiology 2013 13:11
    Content type: Research article Published on:

  43. Estrogen-related receptors (ERRs) are orphan nuclear hormone receptors expressed in metabolically active tissues and modulate numerous homeostatic processes. ERRs do not bind the ligand estrogen, but they are ...

    Authors: Mardi S Byerly, Roy D Swanson, G William Wong and Seth Blackshaw
    Citation: BMC Physiology 2013 13:10
    Content type: Research article Published on:

  44. MiRNAs are essential mediators of many biological processes. The aim of this study was to investigate the dynamics of miRNA-mRNA regulatory networks during exercise and the subsequent recovery period.

    Authors: Alexander G Tonevitsky, Diana V Maltseva, Asghar Abbasi, Timur R Samatov, Dmitry A Sakharov, Maxim U Shkurnikov, Alexey E Lebedev, Vladimir V Galatenko, Anatoly I Grigoriev and Hinnak Northoff
    Citation: BMC Physiology 2013 13:9
    Content type: Research article Published on:

  45. ATP-sensitive K+ channels (KATP channels), NO, prostaglandins, 20-HETE and L-type Ca2+ channels have all been suggested to be involved in oxygen sensing in skeletal muscle arterioles, but the role of the individu...

    Authors: AnhThuc Ngo, Mads Riemann, Niels-Henrik Holstein-Rathlou, Christian Torp-Pedersen and LarsJørn Jensen
    Citation: BMC Physiology 2013 13:8
    Content type: Research article Published on:

  46. Insulin-like growth factor-1 (IGF-1) is produced in various tissues to stimulate protein synthesis under different conditions. It is however, difficult to distinguish effects by locally produced IGF-1 compared...

    Authors: Britt-Marie Iresjö, Johan Svensson, Claes Ohlsson and Kent Lundholm
    Citation: BMC Physiology 2013 13:7
    Content type: Research article Published on:

  47. The vestibular system controls the ion composition of its luminal fluid through several epithelial cell transport mechanisms under hormonal regulation. The semicircular canal duct (SCCD) epithelium has been sh...

    Authors: Satyanarayana R Pondugula, Suresh B Kampalli, Tao Wu, Robert C De Lisle, Nithya N Raveendran, Donald G Harbidge and Daniel C Marcus
    Citation: BMC Physiology 2013 13:6
    Content type: Research article Published on:

  48. Quinine is a natural molecule commonly used as a flavouring agent in tonic water. Diet supplementation with quinine leads to decreased body weight and food intake in rats. Quinine is an in vitro inhibitor of Trpm...

    Authors: Philippe Cettour-Rose, Carole Bezençon, Christian Darimont, Johannes le Coutre and Sami Damak
    Citation: BMC Physiology 2013 13:5
    Content type: Research article Published on:

  49. SLC10A2-mediated reabsorption of bile acids at the distal end of the ileum is the first step in enterohepatic circulation. Because bile acids act not only as detergents but also as signaling molecules in lipid...

    Authors: Tohru Saeki, Kosuke Sato, Shiho Ito, Keisuke Ikeda and Ryuhei Kanamoto
    Citation: BMC Physiology 2013 13:4
    Content type: Research article Published on:

  50. Reactive oxygen species (ROS) are formed under natural physiological conditions and are thought to play an important role in many human diseases. A wide range of antioxidants are involved in cellular defense m...

    Authors: Aline C Caetano, Lucimara F da Veiga, Flávia R Capaldi, Severino M de Alencar, Ricardo A Azevedo and Rosangela MN Bezerra
    Citation: BMC Physiology 2013 13:3
    Content type: Research article Published on:

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