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  1. Research article

    Endothelial dysfunction in the pathogenesis of pre-eclampsia in Ghanaian women

    Pre-eclampsia (PE) remains a disease of theories despite extensive research into its etiology. Alteration in the production of vascular endothelial growth factor (VEGF), a biomarker of endothelial dysfunction,...

    Kwame Adu-Bonsaffoh, Daniel Ansong Antwi, Ben Gyan and Samuel Amenyi Obed

    BMC Physiology 2017 17:5

    Published on: 29 March 2017

  2. Methodology article

    Short-term overfeeding of zebrafish with normal or high-fat diet as a model for the development of metabolically healthy versus unhealthy obesity

    Obese individuals differ in their risk of developing metabolic and cardiovascular complications depending on fat distribution (subcutaneous versus visceral) and adipose tissue (AT) phenotype (hyperplasic versu...

    Kathrin Landgraf, Susanne Schuster, Andrej Meusel, Antje Garten, Thomas Riemer, Dorit Schleinitz, Wieland Kiess and Antje Körner

    BMC Physiology 2017 17:4

    Published on: 21 March 2017

  3. Research article

    Variation in branchial expression among insulin-like growth-factor binding proteins (igfbps) during Atlantic salmon smoltification and seawater exposure

    In preparation for migration from freshwater to marine habitats, Atlantic salmon (Salmo salar L.) undergo smoltification, a transformation that includes the acquisition of hyposmoregulatory capacity. The growth h...

    Jason P. Breves, Chelsea K. Fujimoto, Silas K. Phipps-Costin, Ingibjörg E. Einarsdottir, Björn Thrandur Björnsson and Stephen D. McCormick

    BMC Physiology 2017 17:2

    Published on: 18 January 2017

  4. Research article

    Ryanodine-induced vasoconstriction of the gerbil spiral modiolar artery depends on the Ca2+ sensitivity but not on Ca2+ sparks or BK channels

    In many vascular smooth muscle cells (SMCs), ryanodine receptor-mediated Ca2+ sparks activate large-conductance Ca2+-activated K+ (BK) channels leading to lowered SMC [Ca2+]i and vasodilation. Here we investigate...

    Gayathri Krishnamoorthy, Katrin Reimann and Philine Wangemann

    BMC Physiology 2016 16:6

    Published on: 2 November 2016

  5. Research article

    Trimester-specific thyroid hormone reference ranges in Sudanese women

    Trimester-specific reference ranges for T3, T4, and TSH need to be established in different communities. Neither Sudan nor other African countries have established trimester-specific reference ranges for TSH, ...

    Enaam T. Elhaj, Ishag Adam, Mohamed A. Ahmed and Mohamed F. Lutfi

    BMC Physiology 2016 16:5

    Published on: 31 October 2016

  6. Research article

    Subcellular dissemination of prothymosin alpha at normal physiology: immunohistochemical vis-a-vis western blotting perspective

    The cell type, cell status and specific localization of Prothymosin α (PTMA) within cells seemingly determine its function. PTMA undergoes 2 types of protease proteolytic modifications that are useful in eluci...

    Caroline Mwendwa Kijogi, Christopher Khayeka-Wandabwa, Keita Sasaki, Yoshimasa Tanaka, Hiroshi Kurosu, Hayato Matsunaga and Hiroshi Ueda

    BMC Physiology 2016 16:2

    Published on: 1 March 2016

  7. Research article

    The normal electrocardiograms in the conscious newborn lambs in neonatal period and its progression

    Veterinary cardiology, especially electrocardiography, has shown major advancements for all animal species. Consequently, the number of ovine species used as experimental animals has increased to date. Few stu...

    Karoline Koether, Carla Maria Vela Ulian, Maria Lucia Gomes Lourenço, Renato Souza Gonçalves, Mateus José Sudano, Raíssa Karolliny Salgueiro Cruz, Naiana da Silva Branchini, Angélica Alfonso and Simone Biagio Chiacchio

    BMC Physiology 2016 16:1

    Published on: 19 January 2016

  8. Methodology article

    An investigation of the efficacy and mechanism of contrast-enhanced X-ray Computed Tomography utilizing iodine for large specimens through experimental and simulation approaches

    Iodine-based solutions have long been known to be effective in aiding the differentiation among soft tissues in both fundamental anatomical research and for clinical diagnoses. Recently the combination of this...

    Zhiheng Li, Julia A. Clarke, Richard A. Ketcham, Matthew W. Colbert and Fei Yan

    BMC Physiology 2015 15:5

    Published on: 21 December 2015

  9. Research article

    Hypoxia mediated pulmonary edema: potential influence of oxidative stress, sympathetic activation and cerebral blood flow

    Neurogenic pulmonary edema (NPE) is a non-cardiogenic form of pulmonary edema that can occur consequent to central neurologic insults including stroke, traumatic brain injury, and seizure. NPE is a public heal...

    Shadi Khademi, Melinda A. Frye, Kimberly M. Jeckel, Thies Schroeder, Eric Monnet, Dave C. Irwin, Patricia A. Cole, Christopher Bell, Benjamin F. Miller and Karyn L. Hamilton

    BMC Physiology 2015 15:4

    Published on: 9 October 2015

  10. Research article

    Exercise performed around MLSS decreases systolic blood pressure and increases aerobic fitness in hypertensive rats

    Exercise is a non-pharmacologic agent widely used for hypertension control, where low intensity is often associated with blood pressure reduction. Maximal lactate steady state (MLSS) was recently identified in...

    Bernardo A Petriz, Jeeser A Almeida, Clarissa P C Gomes, Carlos Ernesto, Rinaldo W Pereira and Octavio L Franco

    BMC Physiology 2015 15:1

    Published on: 14 March 2015

  11. Research article

    Alteration in circulating metabolites during and after heat stress in the conscious rat: potential biomarkers of exposure and organ-specific injury

    Heat illness is a debilitating and potentially life-threatening condition. Limited data are available to identify individuals with heat illness at greatest risk for organ damage. We recently described the tran...

    Danielle L Ippolito, John A Lewis, Chenggang Yu, Lisa R Leon and Jonathan D Stallings

    BMC Physiology 2014 14:14

    Published on: 24 December 2014

  12. Research article

    CaMKII content affects contractile, but not mitochondrial, characteristics in regenerating skeletal muscle

    The multi-meric calcium/calmodulin-dependent protein kinase II (CaMKII) is the main CaMK in skeletal muscle and its expression increases with endurance training. CaMK family members are implicated in contracti...

    Wouter Eilers, Richard T Jaspers, Arnold de Haan, Céline Ferrié, Paola Valdivieso and Martin Flück

    BMC Physiology 2014 14:7

    Published on: 17 December 2014

  13. Research article

    White-nose syndrome initiates a cascade of physiologic disturbances in the hibernating bat host

    The physiological effects of white-nose syndrome (WNS) in hibernating bats and ultimate causes of mortality from infection with Pseudogymnoascus (formerly Geomyces) destructans are not fully understood. Increased...

    Michelle L Verant, Carol U Meteyer, John R Speakman, Paul M Cryan, Jeffrey M Lorch and David S Blehert

    BMC Physiology 2014 14:10

    Published on: 9 December 2014

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